Cardiovascular disease (CVD) is the main cause of death in the United States, Canada, United Kingdom, Ireland, and Europe. It accounts for more than 40% of total deaths in these countries. In the United States and Europe, between 6 and 15 million individuals have heart failure (HF) (Fang et al. 2008; Dickstein et al. 2008). In the United States, HF causes more than 900,000 deaths annually (Haldeman et al. 1999), and more than half a million patients are diagnosed with a first episode of HF each year with ∼1 million hospitalizations for HF annually in the United States (Fang et al. 2008).
There is no doubt that cardiac resynchronization therapy (CRT) and...
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