Antiphospholipid Antibody Syndrome
The antiphospholipid syndrome (APS) is an autoimmune thrombophilic condition that is marked by the presence of antibodies that recognize phospholipid-binding proteins (Rand 2007).
The pathophysiologic process associated with antiphospholipid antibody syndrome remains uncertain; however, it includes inhibition of prostacyclin formation or protein C activation. Antibodies affect platelets, limit the production of endothelium-derived relaxing factor, and possibly inhibit the prekallikrein-mediated intrinsic pathway of fibrinolysis. Antiphospholipid antibodies are associated with recurrent fetal loss (typically second- or third-trimester miscarriages), thrombocytopenia, false-positive Venereal Disease Research Laboratory test results, painful leg ulcerations, cardiac valve alterations, and livedo reticularis (Roach et al. 2008).
The principal autoantigen of antiphospholipid antibody syndrome has been shown to be beta-2-glycoprotein 1 (apolipoprotein H), a protein that binds...
- Rand JH (2007) The antiphospholipid syndrome. Hematology 2007(1):136–142Google Scholar