Encyclopedia of Heart Diseases

2011 Edition
| Editors: M. Gabriel Khan

Antihistamines

Reference work entry
DOI: https://doi.org/10.1007/978-1-60761-219-3_13

Overview

The H1-antihistamines have been reclassified as inverse agonists, rather than as H1-receptor antagonists (Simons 2004). The first generation H1-antihistamines are well-known antiallergy medications. They may occasionally cause an increase in the pulse rate because they have an atropine-like effect. In some individuals, the heart rate may become rapid. These sensations, called  palpitations and caused by  arrhythmia, subside over time and usually cause no harm ( Arrhythmias). Patients with angina, however, should be cautious with the use of antihistamines, because an increase in heart rate may trigger an attack of angina ( Angina). Blood pressure is usually not increased by antihistamine use, but many remedies containing antihistamines contain the decongestant phenyl propanolamine, which elevates blood pressure ( Blood Pressure). This should be avoided in patients with hypertension and angina ( Hypertension).

Second-Generation

These agents do not produce the bothersome side...

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Bibliography

References

  1. Junttila JM, Gonzalez M, Lizotte E et al (2008) Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias. Circulation 117:1890–1893PubMedGoogle Scholar
  2. Leurs R, Church MK, Taglialatela M (2002) H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy 32:489–498PubMedGoogle Scholar
  3. Simons F, Estelle R (2004) Advances in H1-antihistamines. New Engl J Med 351(21):2203–2217PubMedGoogle Scholar
  4. Simons FER, Silas P, Portnoy JM et al (2003) Safety of cetirizine in infants 6 to 11 months of age: a randomized, double-blind, placebo-controlled study. J Allergy Clin Immunol 111:1244–1248PubMedGoogle Scholar

Suggested Reading

  1. Yap YG, Behr ER, Camm AJ (2009) Drug-induced Brugada syndrome. Europace 11(8):989–994PubMedGoogle Scholar

Copyright information

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