Encyclopedia of Heart Diseases

2011 Edition
| Editors: M. Gabriel Khan


Reference work entry
DOI: https://doi.org/10.1007/978-1-60761-219-3_13


The H1-antihistamines have been reclassified as inverse agonists, rather than as H1-receptor antagonists (Simons 2004). The first generation H1-antihistamines are well-known antiallergy medications. They may occasionally cause an increase in the pulse rate because they have an atropine-like effect. In some individuals, the heart rate may become rapid. These sensations, called  palpitations and caused by  arrhythmia, subside over time and usually cause no harm ( Arrhythmias). Patients with angina, however, should be cautious with the use of antihistamines, because an increase in heart rate may trigger an attack of angina ( Angina). Blood pressure is usually not increased by antihistamine use, but many remedies containing antihistamines contain the decongestant phenyl propanolamine, which elevates blood pressure ( Blood Pressure). This should be avoided in patients with hypertension and angina ( Hypertension).


These agents do not produce the bothersome side...

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Suggested Reading

  1. Yap YG, Behr ER, Camm AJ (2009) Drug-induced Brugada syndrome. Europace 11(8):989–994PubMedGoogle Scholar

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