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EGFR (ErbB) Signaling Pathways in Pancreatic Cancer Pathogenesis

  • Monique Williams
  • Gwen Lomberk
  • Raul Urrutia
Reference work entry

Abstract

The epidermal growth factor receptor (EGFR/ErbB) signaling axis influences the development, maintenance, and disease of tissues throughout the body. Effects have been demonstrated on normal cell proliferation, migration, differentiation, adhesion, and apoptosis in pancreas as well as heart, muscle, nervous system, and a wide variety of organ epithelia. In addition, alterations in the epidermal growth factor (EGF) pathway, including overexpression of the ErbB family of receptor tyrosine kinases, mutations in downstream mediators (e.g., Ras), as well as aberrant signaling, are present in the vast majority of pancreatic and other solid tissue tumors. The importance of the ErbB signaling axis to cancer is illustrated by the number of articles and reviews published on this topic to date (>20,000 and >3000, respectively). In line with the importance of ErbB signaling to cancer, several anticancer therapies have been developed targeting various parts of the ErbB signaling axis and are currently in use, with more undergoing intense development and investigation. Presently, the NIH currently cites an extensive list of clinical studies of ErbB signaling in cancer.

Keywords

ErbB Epidermal growth factor EGF EGFR Signaling Pancreatic cancer Therapy Molecular imaging 

Notes

Acknowledgments

Work in the authors’ laboratories is supported by NIH DK52913 (to RU), NIH CA178627 (to GL), ChiRhoClin, Research Institute (to RU and GL), as well as the Mayo Clinic SPORE in Pancreatic Cancer (P50 CA102701).

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Department of MedicineMayo ClinicRochesterUSA
  2. 2.Division of Research, Department of SurgeryMedical College of WisconsinMilwaukeeUSA
  3. 3.Division of Research, Department of Surgery and Genomic Sciences and Precision Medicine Center (GSPMC)Medical College of WisconsinMilwaukeeUSA

Section editors and affiliations

  • Raul A. Urrutia
    • 1
  • Markus W. Büchler
    • 2
  • John Neoptolemos
    • 3
  • Thilo Hackert
    • 4
  1. 1.Mayo Clinic Cancer CenterMayo ClinicRochesterUSA
  2. 2.Department of General, Visceral and Transplantation SurgeryUniversity of HeidelbergHeidelbergGermany
  3. 3.Division of Surgery and OncologyUniversity of LiverpoolLiverpoolUK
  4. 4.Department of General, Visceral and Transplantation SurgeryUniversity of HeidelbergHeidelbergGermany

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