Definition
Barrier-to-autointegration factor (BAF or BANF1) is a highly conserved 10-KDa protein in multicellular eukaryotes. It was identified as a factor that blocks integration of Moloney murine leukemia virus DNA into itself (autointegration) in vitro. BAF binds DNA nonspecifically and, because it is a dimer, bridges together DNA molecules. BAF also binds the LEM domain, a domain that is shared among lamina-associated polypeptide 2, emerin, and MAN1. BAF is an essential cellular protein, and knockdown or knockout results in a defect in chromosome segregation during mitosis.
Introduction
A role for barrier-to-autointegration factor (BAF or BANF1) in retroviral DNA integration was first inferred from in vitro experiments with Moloney murine leukemia virus. After entry of a virion into the cytoplasm of a newly infected cell, reverse transcriptionoccurs within the reverse transcription complex, a nucleoprotein complex derived from the core of the infecting virion. The resulting...
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Zhuang, X., Craigie, R. (2018). BAF (BANF1). In: Hope, T.J., Richman, D.D., Stevenson, M. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7101-5_68
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DOI: https://doi.org/10.1007/978-1-4939-7101-5_68
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