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Stem Cell Transplantation

  • Reference work entry
  • First Online:
Encyclopedia of AIDS

  • 36 Accesses

Definition

Stem Cell Transplantation (SCT), also referred to as bone marrow transplantation or hematopoietic stem cell transplantation is a treatment in which hematopoietic stem cells are administered to a patient, usually as treatment for hematologic cancer or bone marrow failure. Prior to infusion of stem cells, patients receive fully myeloablative or reduced-intensity chemotherapy both to reduce tumor burden and to allow engraftment of the stem cells. There are several potential sources of the hematopoietic stem cells in clinical use. In autologous SCT, hematopoietic stem cells are collected from the patient prior to chemotherapy and infused after treatment to rescue the hematopoietic system. In allogeneic SCT, hematopoietic stem cells are donated by a close relative or genetically matched unrelated individual and infused after conditioning chemotherapy. Availability of suitably matched donors remains a major limitation to SCT and new advances now allow for more flexibility in...

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Authors and Affiliations

  1. Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MA, USA

    Christine Durand

  2. Department of Oncology, Division of Hematologic Malignancies, Johns Hopkins University School of Medicine, Baltimore, MA, USA

    Richard Ambinder

Authors
  1. Christine Durand
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  2. Richard Ambinder
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Corresponding author

Correspondence to Christine Durand .

Editor information

Editors and Affiliations

  1. Department of Cell and Molecular Biology, Northwestern University, Robert H. Lurie Medical Research Center, Chicago, IL, USA

    Thomas J. Hope

  2. VA San Diego Healthcare System and University of California San Diego, La Jolla, CA, USA

    Douglas D. Richman

  3. Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA

    Mario Stevenson

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Durand, C., Ambinder, R. (2018). Stem Cell Transplantation. In: Hope, T.J., Richman, D.D., Stevenson, M. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7101-5_24

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  • DOI: https://doi.org/10.1007/978-1-4939-7101-5_24

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-7100-8

  • Online ISBN: 978-1-4939-7101-5

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