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Cerebral Palsy

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Atlas of Genetic Diagnosis and Counseling

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Abstract

Cerebral palsy (CP) is currently considered as a clinically defined symptom complex applied to individuals with a static, nonprogressive motor impairment of early onset that is cerebral in origin. It describes a group of motor impairment syndromes secondary to genetic and acquired disorders of the developing brain. Therefore, it is not a single entity with respect to pathogenesis but rather an etiologically heterogeneous entity with multiple possible causes that result in an aberration or injury to the maturing central nervous system. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, cognition, communication, perception, and/or behavior and/or by a seizure disorder. The prevalence is estimated between 1.5 and 2.5 per 1,000 live births (Ferriero 1999).

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References

  • Agarwal, A., & Verma, I. (2012). Cerebral palsy in children: An overview. Journal of Clinical Orthopaedics and Trauma, 3, 77–81.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ashwal, S., Russman, B. S., Blasco, P. A., et al. (2004). Practice parameter: Diagnostic assessment of the child with cerebral palsy. Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology, 62, 851–863.

    Article  CAS  PubMed  Google Scholar 

  • Balakrishnan, B., Nance, E., Johnston, M. V., et al. (2013). Nanomedicine in cerebral palsy. International Journal of Nanomedicine, 8, 4183–4195.

    PubMed  PubMed Central  Google Scholar 

  • Bax, M., Goldstein, M., Rosenbaum, P., et al. (2005). Proposed definition and classification of cerebral palsy, April 2005. Developmental Medicine and Child Neurology, 47, 571–576.

    Article  PubMed  Google Scholar 

  • Berker, A. N., & Yalçin, M. S. (2008). Cerebral palsy: Orthopedic aspects and rehabilitation. Pediatric Clinics of North America, 55, 1209–1225.

    Article  PubMed  Google Scholar 

  • Blair, E., Watson, L., Badawi, N., et al. (2001). Life expectancy among people with cerebral palsy in Western Australia. Developmental Medicine and Child Neurology, 43, 508–515.

    Article  CAS  PubMed  Google Scholar 

  • Chinnery, D. F. (2014). Mitochondrial disorders overview. GeneReviews. Updated August 14, 2014. Available at UTP: http://www.ncbi.nlm.nih.gov/books/BNBK1224/.

  • Dodge, N. N. (2008). Cerebral palsy: Medical aspects. Pediatric Clinics of North America, 55, 89–1207.

    Article  Google Scholar 

  • Dougherty, N. J. (2009). A review of cerebral palsy for the oral health professional. Dental Clinics of North America, 53, 329–338.

    Article  PubMed  Google Scholar 

  • Evans, P. M., Evans, S. J. W., & Alberman, E. (1990). Cerebral palsy: Why we must plan for survival. Archives of Disease in Childhood, 65, 1329–1333.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ferriero, D. H. (1999). Cerebral palsy: Diagnosing something that is not one thing. Current Opinion in Pediatrics, 11, 485–486.

    Article  CAS  PubMed  Google Scholar 

  • Finckh, U., Schroder, J., Ressler, B., et al. (2000). Spectrum and detection rate of L1CAM mutations in isolated and familial cases with clinically suspected L1-disease. American Journal of Medical Genetics, 92, 40–46.

    Article  CAS  PubMed  Google Scholar 

  • Fisher, R. L., & Russman, B. S. (1974). Genetic syndromes associated with cerebral palsy. Clinical Orthopaedics and Related Research, 99, 2–11.

    Article  Google Scholar 

  • Fryer, A., Appleton, R., Sweeney, M. G., et al. (1994). Mitochondrial DNA 8993 (NARP) mutation presenting with a heterogeneous phenotype including cerebral palsy. Archives of Disease in Childhood, 71, 419–422.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Garne, E., Dolk, H., Krägeloh-Mann, I., et al. (2008). Cerebral palsy and congenital malformations. European Journal of Paediatric Neurology, 12, 82–88.

    Article  PubMed  Google Scholar 

  • Green, L., Greenberg, G. M., & Hurwitz, E. (2003). Primary care of children with cerebral palsy. Clinics in Family Practice, 5, 467–491.

    Article  Google Scholar 

  • Guerrini, R., Moro, F., Kato, M., et al. (2007). Expansion of the first PolyA tract of ARX causes infantile spasms and status dystonicus. Neurology, 69, 427–433.

    Article  CAS  PubMed  Google Scholar 

  • Kavčič, A., & Vodušek, D. B. (2005). A historical perspective on cerebral palsy as a concept and a diagnosis. European Journal of Neurology, 12, 582–587.

    Article  PubMed  Google Scholar 

  • Krägeloh-Mann, I., & Cans, C. (2009). Cerebral palsy update (Review). Brain and Development, 31, 537–544.

    Article  PubMed  Google Scholar 

  • Kuban, K. C. K., & Leviton, A. (1994). Cerebral palsy. The New England Journal of Medicine, 330, 188–195.

    Article  CAS  PubMed  Google Scholar 

  • Liptak, G. S. (2005). Complementary and alternative therapies for cerebral palsies. Mental Retardation and Developmental Disabilities Research Reviews, 11, 156–163.

    Article  PubMed  Google Scholar 

  • Paneth, N. (1986). Etiologic factors in cerebral palsy. Pediatric Annals, 15, 191–201.

    Article  CAS  PubMed  Google Scholar 

  • Paneth, N. (2008). Establishing the diagnosis of cerebral palsy. Clinical Obstetrics and Gynecology, 51, 742–748.

    Article  PubMed  Google Scholar 

  • Panteliadis, C. P. (2004). Classification. In C. P. Panteliadis & H. M. Strassburg (Eds.), Cerebral palsy: Principles and management. Stuttgart: Thieme.

    Google Scholar 

  • Poulton, J., & Turnbull, D. M. (2000). 74th ENMC international workshop: Mitochondrial diseases 19–20 November 1999, Naarden, the Netherlands. Neuromuscular Disorders, 10, 460–462.

    Article  CAS  PubMed  Google Scholar 

  • Rogers, B. (2004). Feeding method and health outcomes of children with cerebral palsy. Journal of Pediatrics, 145, S28–S32.

    Article  PubMed  Google Scholar 

  • Russman, B. S., & Ashwal, S. (2004). Evaluation of the child with cerebral palsy. Seminars in Pediatric Neurology, 11, 47–57.

    Article  PubMed  Google Scholar 

  • Sanger, T. D., Delgado, M. R., Gaebler-Spira, D., et al. (2003). Classification and definition of disorders causing hypertonia in childhood. Pediatrics, 111, e89–e97.

    Article  PubMed  Google Scholar 

  • Schaefer, G. B. (2008). Genetic s considerations in cerebral palsy. Seminars in Pediatric Neurology, 15, 21–26.

    Article  PubMed  Google Scholar 

  • Shevell, M. I., Majnemer, A., & Morin, I. (2003). Etiologic yield of cerebral palsy: A contemporary case series. Pediatric Neurology, 28, 352–359.

    Article  PubMed  Google Scholar 

  • Shimony, J. S., Lawrence, R., Neil, J. J., et al. (2008). Imaging for diagnosis and treatment of cerebral palsy. Clinical Obstetrics and Gynecology, 51, 787–799.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Medical Genetics, Shriners Hospitals for Children, Perinatal and Clinical Genetics, Department of Pediatrics, LSU Health Sciences Center, Shreveport, LA, USA

    Harold Chen

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  1. Harold Chen
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Chen, H. (2017). Cerebral Palsy. In: Atlas of Genetic Diagnosis and Counseling. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2401-1_35

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  • DOI: https://doi.org/10.1007/978-1-4939-2401-1_35

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2400-4

  • Online ISBN: 978-1-4939-2401-1

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