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Drug Resistance in Leishmania

  • Danielle Légaré
  • Marc OuelletteEmail author
Reference work entry

Abstract

Protozoan parasites of the genus Leishmania cause a wide range of diseases affecting 12 million people worldwide with 1.5–2 million new cases each year. With no vaccine available yet, the control of these parasites relies solely on chemotherapy. Low-cost antimony-derived compounds remain the primary antileishmanial treatment in most developing countries. Increasing drug resistance towards these molecules has forced the use of alternative therapies in highly endemic areas including amphotericin B, paromomycin, and miltefosine. This chapter is presenting our current understanding of the mode of action and underlying resistance mechanisms of the few therapeutic drugs used against Leishmania.

Keywords

Leishmania Drug resistance Pentavalent antimonials Amphotericin B Miltefosine Paromomycin 

Abbreviations

AMB

Amphotericin B

CL

Cutaneous leishmaniasis

DCL

Diffuse cutaneous leishmaniasis

GSH

Glutathione

MCL

Mucocutaneous leishmaniasis

MIL

Miltefosine

PKDL

Post-kala-azar dermal leishmaniasis

PM

Paromomycin

SAG

Sodium antimony gluconate

SbIII

Trivalent antimonials

SbV

Pentavalent antimonials

SILAC

Stable isotope labeling by amino acids in cell culture

TSH

Trypanothione

VL

Visceral leishmaniasis

Notes

Acknowledgments

The authors are grateful to the members of the laboratory at the Centre de Recherche en Infectiologie du CHU de Québec for their dedication, professionalism, and critical reading of the manuscript. The authors owe an apology to their colleagues in the field of leishmaniasis and even wider area of drug resistance whose work could not be properly acknowledged due to space limitations. This work was funded by a CIHR grant to M.O. M.O. holds the Canada Research Chair in Antimicrobial Resistance.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Centre de Recherche en Infectiologie du Centre de Recherche du CHU de Québec, Pavillon CHUL and Département de Microbiologie-Infectiologie et Immunologie, Faculté de MédecineUniversité LavalQCCanada

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