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Nucleus and Genome: DNA Replication

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Molecular Biology

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Introduction

One of the most fundamental features of all living organisms, either unicellular or multicellular, is their ability to reproduce. This relies primarily on the premise that their genetic material, the DNA, must be preserved from one generation to the next. In unicellular organisms, a single cell division leads to two new ones. In the case of multicellular organisms, made up of trillions of cells, the single fact of becoming an adult requires that the single zygotic cell and its descendants undergo an enormous amount of cell divisions to attain the large number of cells that conform the organism. In addition, during the adult life, cell homeostasis is a highly dynamic process that involves both the death of many cells and their continuous replacement with newly formed ones. These new cells are derived from special cell types, the stem cells, which are confined in certain niches within the body. The case of the renewal of blood cells or the epithelial cells in the gut, in...

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References

  • Aparicio OM. Location, location, location: it’s all in the timing for replication origins. Genes Dev. 2013;27:117–28.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Arias EE, Walter JC. Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev. 2007;21:497–518.

    Article  CAS  PubMed  Google Scholar 

  • Bell S, Méchali M, DePamphilis ML. DNA replication. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 2012.

    Google Scholar 

  • Blow JJ, Laskey RA. A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature. 1988;332:546–8.

    Article  CAS  PubMed  Google Scholar 

  • Blow JJ, Ge XQ, Jackson DA. How dormant origins promote complete genome replication. Trends Biochem Sci. 2011;36:405–14.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Breuer C, Ishida T, Sugimoto K. Developmental control of endocycles and cell growth in plants. Curr Opin Plant Biol. 2010;13:654–60.

    Article  CAS  PubMed  Google Scholar 

  • Brewer BJ, Fangman WL. The localization of replication origins on ARS plasmids in S. cerevisiae. Cell. 1987;6:463–71.

    Article  Google Scholar 

  • Bryant JA. Replication of nuclear DNA. Progr Bot. 2010;71:25–60.

    Article  Google Scholar 

  • Caro E, Castellano MM, Gutierrez C. A chromatin link that couples cell division to root epidermis patterning in Arabidopsis. Nature. 2007;447:213–7.

    Article  CAS  PubMed  Google Scholar 

  • Costas C, de la Paz Sanchez M, Stroud H, Yu Y, Oliveros JC, Feng S, Benguria A, López-Vidriero I, Zhang X, Solano R, Jacobsen SE, Gutierrez C. Genome-wide mapping of Arabidopsis thaliana origins of DNA replication and their associated epigenetic marks. Nat Struct Mol Biol. 2011a;18:395–400.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Costas C, Sanchez MP, Sequeira-Mendes J, Gutierrez C. Progress in understanding DNA replication control. Plant Sci. 2011b;181:203–9.

    Article  CAS  PubMed  Google Scholar 

  • De Veylder L, Larkin JC, Schnittger A. Molecular control and function of endoreplication in development and physiology. Trends Plant Sci. 2011;16:624–34.

    Article  PubMed  Google Scholar 

  • DePamphilis ML, Bell S. Genome duplication. Concepts, mechanisms, evolution, and disease. London: Garland Science/Taylor & Francis Group; 2011.

    Google Scholar 

  • Edgar BA, Zielke N, Gutierrez C. Nat Rev Mol Cell Biol. 2014;15:197–210.

    Article  PubMed  Google Scholar 

  • Gilbert DM. Evaluating genome-scale approaches to eukaryotic DNA replication. Nat Rev Genet. 2010;11:673–84.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gutierrez C. Coupling cell proliferation and development in plants. Nat Cell Biol. 2005;7:535–41.

    Article  CAS  PubMed  Google Scholar 

  • Gutierrez C. The Arabidopsis cell cycle. In The Arabidopsis Book.e0120 http://www.aspb.org/publications/arabidopsis/2009

  • Hernandez P, Bjerknes CA, Lamm SS, Van’t Hof J. Proximity of an ARS consensus sequence to a replication origin of pea (Pisum sativum). Plant Mol Biol. 1988;10:413–22.

    Article  CAS  PubMed  Google Scholar 

  • Hiratani I, Takebayashi S, Lu J, Gilbert DM. Replication timing and transcriptional control: beyond cause and effect–part II. Curr Opin Genet Dev. 2009;19:142–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Inze D, De Veylder L. Cell cycle regulation in plant development. Annu Rev Genet. 2006;40:77–105.

    Article  CAS  PubMed  Google Scholar 

  • Jacob Y, Stroud H, Leblanc C, Feng S, Zhuo L, Caro E, Hassel C, Gutierrez C, Michaels SD, Jacobsen SE. Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature. 2010;466:987–91.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Jeske H. Geminiviruses. Curr Top Microbiol Immunol. 2009;331:185–226.

    CAS  PubMed  Google Scholar 

  • Labib K, Gambus A. A key role for the GINS complex at DNA replication forks. Trends Cell Biol. 2007;2007(17):271–8.

    Article  Google Scholar 

  • Lee TJ, Pascuzzi PE, Settlage SB, Shultz RW, Tanurdzic M, Rabinowicz PD, Menges M, Zheng P, Main D, Murray JA, Sosinski B, Allen GC, Martienssen RA, Hanley-Bowdoin L, Vaughn MW, Thompson WF. Arabidopsis thaliana chromosome 4 replicates in two phases that correlate with chromatin state. PLoS Genet. 2010;6:e1000982.

    Article  PubMed Central  PubMed  Google Scholar 

  • Luque A, Sanz-Burgos AP, Ramirez-Parra E, Castellano MM, Gutierrez C. Interactionof geminivirus Rep protein with replication factor C ans its potential during geminivirus DNA replication. Virology 2002;302:83–94.

    Article  CAS  PubMed  Google Scholar 

  • Mechali M. Eukaryotic DNA, replication origins: many choices for appropriate answers. Nat Rev Mol Cell Biol. 2010;11:728–38.

    Article  CAS  PubMed  Google Scholar 

  • Ramirez-Parra E, Gutierrez C. The many faces of chromatin assembly factor 1. Trends Plant Sci. 2007;12:570–6.

    Article  CAS  PubMed  Google Scholar 

  • Schvartzman JB, Chenet B, Bjerknes C, Van’t Hof J. Nascent replicons are synchronously joined at the end of S phase or during G2 phase in peas. Biochim Biophys Acta. 1981;653:185–92.

    Article  CAS  PubMed  Google Scholar 

  • Segurado M, de Luis A, Antequera F. Genome-wide distribution of DNA replication origins at A+T-rich islands in Schizosaccharomyces pombe. EMBO Rep. 2003;4:1048–53.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Shultz RW, Tatineni VM, Hanley-Bowdoin L, Thompson WF. Genome-wide analysis of the core DNA replication machinery in the higher plants Arabidopsis and rice. Plant Physiol. 2007;144:1697–714.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Taylor JH, Woods PS, Hughes WL. The organization and duplication of chromosomes as revealed by autoradiographic studies using tritium-labeled thymidine. Proc Natl Acad Sci USA. 1957;43:122–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Centro de Biología Molecular ‘Severo Ochoa’, Consejo Superior de Investigacion, Universidad Autónoma de Madrid (UAM), Nicolas Cabrera 1, Cantoblanco, 28049, Madrid, Spain

    Crisanto Gutierrez, Joana Sequeira-Mendes & Irene Aragüez

Authors
  1. Crisanto Gutierrez
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  2. Joana Sequeira-Mendes
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  3. Irene Aragüez
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Corresponding author

Correspondence to Crisanto Gutierrez .

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Editors and Affiliations

  1. Ames, Iowa, USA

    Stephen H. Howell

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Gutierrez, C., Sequeira-Mendes, J., Aragüez, I. (2013). Nucleus and Genome: DNA Replication. In: Howell, S. (eds) Molecular Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0263-7_1-1

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  • DOI: https://doi.org/10.1007/978-1-4939-0263-7_1-1

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  • Online ISBN: 978-1-4939-0263-7

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