Definition
antiSMASH (Medema et al. 2011) is a web server and a stand-alone software to identify, annotate, and compare gene clusters that encode the biosynthesis of secondary metabolites in bacterial and fungal genomes. antiSMASH offers a wide range of options to identify and analyze biosynthetic gene clusters, including protein domain analysis of the large multi-domain enzymatic assembly lines involved, prediction of core chemical structures of their end compounds, and multiple cluster alignments to a database of all currently sequenced gene clusters.
The antiSMASH web server can be found at http://antismash.secondarymetabolites.org.
Introduction
Microbial secondary metabolites are of great interest to society because of their diverse biological activities that are interesting starting points for drug development. Many of them are already used as antibiotics, antitumor agents, or cholesterol-lowering drugs (Hutchinson and McDaniel 2001; Fischbach and Walsh 2009). Automated...
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Takano, E., Breitling, R., Medema, M.H. (2015). antiSMASH. In: Nelson, K.E. (eds) Encyclopedia of Metagenomics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7478-5_703
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DOI: https://doi.org/10.1007/978-1-4899-7478-5_703
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