Chronic Respiratory Disease, Asthma
Lung microbiome in asthma; Microbiota in asthma
The types, distribution, and environmental interactions of airway-associated microbial populations in individuals with asthma.
The purpose of this entry is to introduce and summarize current knowledge of the airway microbiome in asthma. The relationships between asthma and microbial exposures, colonization, or infection have been postulated and studied for decades (Huang and Lynch 2011; Huang 2013). Although acute respiratory infections can trigger exacerbations of asthma, chronic colonization or infection of the respiratory tract by specific organisms has also been linked to asthma (Martin et al. 2001; Johnston and Martin 2005; Bisgaard et al. 2007). Earlier studies, which have been reviewed recently (Huang and Lynch 2011), used primarily culture methods, serologic antibody assays, or targeted molecular tests to detect exposure to, or infection by, specific microbes. The focus of this entry is to present...