Encyclopedia of Metagenomics

2015 Edition
| Editors: Sarah K. Highlander, Francisco Rodriguez-Valera, Bryan A. White

Chronic Respiratory Disease, COPD

  • Yvonne Huang
Reference work entry
DOI: https://doi.org/10.1007/978-1-4899-7475-4_698


Airway microbiome in COPD; Microbiota in COPD


The types, distribution, and environmental interactions of microbial communities present in the lungs of individuals with chronic obstructive pulmonary disease (COPD).


Definition of COPD

The purpose of this entry is to introduce and summarize current knowledge of the airway microbiome in chronic obstructive pulmonary disease (COPD), a smoking-related illness. COPD is a highly prevalent disorder characterized by airflow obstruction that is not completely reversible and which exhibits increasing morbidity and mortality (Han et al. 2012). Classically two forms of clinical presentation were defined for COPD: chronic bronchitis and emphysema. Chronic bronchitis is characterized by excessive mucus production that results in airflow obstruction in the proximal airways. Emphysema is characterized by destruction of distal airway spaces in the lung, where gas exchange takes place.

However, COPD is now recognized to be...

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Pulmonary and Critical Care Medicine, School of MedicineUniversity of California San FranciscoSan FranciscoUSA