Chronic Respiratory Disease, COPD
Airway microbiome in COPD; Microbiota in COPD
The types, distribution, and environmental interactions of microbial communities present in the lungs of individuals with chronic obstructive pulmonary disease (COPD).
Definition of COPD
The purpose of this entry is to introduce and summarize current knowledge of the airway microbiome in chronic obstructive pulmonary disease (COPD), a smoking-related illness. COPD is a highly prevalent disorder characterized by airflow obstruction that is not completely reversible and which exhibits increasing morbidity and mortality (Han et al. 2012). Classically two forms of clinical presentation were defined for COPD: chronic bronchitis and emphysema. Chronic bronchitis is characterized by excessive mucus production that results in airflow obstruction in the proximal airways. Emphysema is characterized by destruction of distal airway spaces in the lung, where gas exchange takes place.
However, COPD is now recognized to be...
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