Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson

Merkel Cell Polyomavirus (MCV)

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_8-1

Definition

Merkel cell polyomavirus (MCV) is a recently discovered member of the Polyomaviridae, a family of small DNA viruses that replicate in the nucleus of their host cell. MCV is one of the ten identified polyomaviruses that naturally infect humans and furthermore one of four polyomaviruses that are known to cause severe human disease, predominantly in immunosuppressed or immunodeficient individuals. Of these, MCV is of particular interest since it presently is the only human polyomavirus known to be involved in tumorigenesis. The virus was first identified in 2008 in tissue from Merkel Cell Carcinoma and Other HIV-associated Skin Cancers by high-throughput sequencing (Feng et al. 2008). Considerable evidence suggests that MCV is causally linked to MCC pathogenesis: Viral DNA is monoclonally integrated into the genome of the tumor cells in up to 90 % of all MCV cases, and the integrated MCV genomes furthermore harbor signature mutations that selectively abrogate viral replication...

Keywords

Chronic Lymphocytic Leukemia Merkel Cell Carcinoma Human Polyomavirus Merkel Cell Polyomavirus Renal Proximal Tubule Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

Journal Articles

  1. An P, Saenz Robles MT, Pipas JM. Large T antigens of polyomaviruses: amazing molecular machines. Annu Rev Microbiol. 2012;66:213–36.PubMedCrossRefGoogle Scholar
  2. Chang Y, Moore PS. Merkel cell carcinoma: a virus-induced human cancer. Annu Rev Pathol. 2012;7:123–44.PubMedCrossRefPubMedCentralGoogle Scholar
  3. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319(5866):1096–100.PubMedCrossRefPubMedCentralGoogle Scholar
  4. Neumann F, Borchert S, Schmidt C, Reimer R, Hohenberg H, Fischer N, Grundhoff A. Replication, gene expression and particle production by a consensus Merkel cell polyomavirus (MCPyV) genome. PLoS One. 2011;6(12):e29112.PubMedCrossRefPubMedCentralGoogle Scholar
  5. Pastrana DV, Wieland U, Silling S, Buck CB, Pfister H. Positive correlation between Merkel cell polyomavirus viral load and capsid-specific antibody titer. Med Microbiol Immunol. 2012;201(1):17–23.PubMedCrossRefPubMedCentralGoogle Scholar
  6. Paulson KG, Iyer JG, Tegeder AR, Thibodeau R, Schelter J, Koba S, Schrama D, Simonson WT, Lemos BD, Byrd DR, Koelle DM, Galloway DA, Leonard JH, Madeleine MM, Argenyi ZB, Disis ML, Becker JC, Cleary MA, Nghiem P. Transcriptome-wide studies of Merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival. J Clin Oncol. 2011;29(12):1539–46.PubMedCrossRefPubMedCentralGoogle Scholar
  7. Schowalter RM, Pastrana DV, Pumphrey KA, Moyer AL, Buck CB. Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin. Cell Host Microbe. 2010;7(6):509–15.PubMedCrossRefPubMedCentralGoogle Scholar
  8. Schowalter RM, Pastrana DV, Buck CB. Glycosaminoglycans and sialylated glycans sequentially facilitate Merkel cell polyomavirus infectious entry. PLoS Pathog. 2011;7(7):e1002161.PubMedCrossRefPubMedCentralGoogle Scholar
  9. Schrama D, Peitsch WK, Zapatka M, Kneitz H, Houben R, Eib S, Haferkamp S, Moore PS, Shuda M, Thompson JF, Trefzer U, Pfohler C, Scolyer RA, Becker JC. Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma. J Invest Dermatol. 2011;131(8):1631–8.PubMedCrossRefGoogle Scholar
  10. Schrama D, Ugurel S, Becker JC. Merkel cell carcinoma: recent insights and new treatment options. Curr Opin Oncol. 2012;24(2):141–9.PubMedCrossRefGoogle Scholar
  11. Sihto H, Kukko H, Koljonen V, Sankila R, Bohling T, Joensuu H. Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma. Clin Cancer Res. 2011;17(14):4806–13.PubMedCrossRefGoogle Scholar
  12. Sihto H, Bohling T, Kavola H, Koljonen V, Salmi M, Jalkanen S, Joensuu H. Tumor infiltrating immune cells and outcome of Merkel cell carcinoma: a population-based study. Clin Cancer Res. 2012;18(10):2872–81.PubMedCrossRefGoogle Scholar
  13. Tolstov YL, Knauer A, Chen JG, Kensler TW, Kingsley LA, Moore PS, Chang Y. Asymptomatic primary Merkel cell polyomavirus infection among adults. Emerg Infect Dis. 2011;17(8):1371–80.PubMedCrossRefPubMedCentralGoogle Scholar
  14. Wieland U, Kreuter A. Merkel cell polyomavirus infection and Merkel cell carcinoma in HIV-positive individuals. Curr Opin Oncol. 2011;23(5):488–93.PubMedCrossRefGoogle Scholar
  15. Wieland U, Mauch C, Kreuter A, Krieg T, Pfister H. Merkel cell polyomavirus DNA in persons without merkel cell carcinoma. Emerg Infect Dis. 2009;15(9):1496–8.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Institute for Medical Microbiology, Virology and HygieneUniversity Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.Heinrich Pette Institute, Leibniz Institute for Experimental VirologyHamburgGermany