Merkel Cell Polyomavirus (MCV)
Merkel cell polyomavirus (MCV) is a recently discovered member of the Polyomaviridae, a family of small DNA viruses that replicate in the nucleus of their host cell. MCV is one of the ten identified polyomaviruses that naturally infect humans and furthermore one of four polyomaviruses that are known to cause severe human disease, predominantly in immunosuppressed or immunodeficient individuals. Of these, MCV is of particular interest since it presently is the only human polyomavirus known to be involved in tumorigenesis. The virus was first identified in 2008 in tissue from Merkel Cell Carcinoma and Other HIV-associated Skin Cancers by high-throughput sequencing (Feng et al. 2008). Considerable evidence suggests that MCV is causally linked to MCC pathogenesis: Viral DNA is monoclonally integrated into the genome of the tumor cells in up to 90 % of all MCV cases, and the integrated MCV genomes furthermore harbor signature mutations that selectively abrogate viral replication...
KeywordsChronic Lymphocytic Leukemia Merkel Cell Carcinoma Human Polyomavirus Merkel Cell Polyomavirus Renal Proximal Tubule Epithelial Cell
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