Definition
The term “virus maturation” in general refers to alterations of the architecture of a virus that occur after the particle with all its constituents has been formed. In the case of HIV-1 and other retroviruses, maturation involves cleavage of the main structural polyprotein, Gag, by the virus-encoded protease once the immature virion is released from the cell. Gag proteolysis results in dramatic changes of the virus morphology that are essential for HIV-1 infectivity. Inhibitors of proteolytic maturation are commonly used as antiviral drugs in current regimens for treatment of HIV-infected patients.
HIV-1 Particle Maturation: What Is It and What Is It Good for?
Viruses may be regarded as “miniaturized” forms of life, reduced to the bare necessities required to ensure efficient replication. They employ various strategies of “genetic economy” to increase the amount of information encoded in a minimal length genome. An important genetic economy strategy is the production of...
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Müller, B., Kräusslich, HG. (2013). HIV-1 Maturation. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_59-1
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DOI: https://doi.org/10.1007/978-1-4614-9610-6_59-1
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