HIV-2 Diagnosis and Viral Load Measurements
Detection and/or quantification of the presence of HIV-2 in biological materials, distinguishable from related lentiviruses, either directly as virus-specific nucleic acid or protein or indirectly as immunological responses to infection. Viral load measurements relate specifically to genome quantification and infection dynamics, usually within already diagnosed individuals.
Human immunodeficiency virus type 2 (HIV-2), a member of the Retroviridae, represents a related but distinct group of infections to HIV-1, the global agent of acquired immunodeficiency syndrome (AIDS). While HIV-2 bears similarity to HIV-1, it represents a separate genetic, virologic, and epidemiologic entity of viruses with marked differences in natural history and disease associations (HIV Prevention in the Correctional System). Accurate, reliable diagnosis of HIV-2 infections is important not only from an individual perspective but when considering wider epidemiological and clinical...
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- Andersson S, Norrgren H, da Silva Z, Biague A, Bamba S, Kwok S, Christopherson C, Biberfeld G, Albert J. Plasma viral load in HIV-1 and HIV-2 singly and dually infected individuals in Guinea-Bissau, West Africa: significantly lower plasma virus set point in HIV-2 infection than in HIV-1 infection. Arch Intern Med. 2000;160(21):3286–93.PubMedCrossRefGoogle Scholar
- Blaak H, Boers PH, Schutten M, van der Endeñ ME, Osterhaus AD. HIV-2-infected individuals with undetectable plasma viremia carry replication-competent virus in peripheral blood lymphocytes. J AIDS. 2004;36(3):777–82.Google Scholar
- Damond F, Benard A, Ruelle J, Alabi A, Kupfer B, Gomes P, Rodes B, Albert J, Boni J, Garson J, Ferns B, Matheron S, Chene G, Brun-Vezinet F. ACHIEV2E collaboration on HIV-2 Infection Study Group. Quality control assessment of HIV-2 viral load quantification assays: results from an international collaboration on HIV-2 infection in 2006. J Clin Microbiol. 2008;46:2088–91.PubMedCrossRefPubMedCentralGoogle Scholar
- Gottlieb GS, Sow PS, Hawes SE, Ndoye I, Redman M, Coll-Seck AM, Faye-Niang MA, Diop A, Kuypers JM, Critchlow CW, Respess R, Mullins JI, Kiviat NB. Equal plasma viral loads predict a similar rate of CD4+ T cell decline in human immunodeficiency virus (HIV) type 1- and HIV-2-infected individuals from Senegal, West Africa. J Infect Dis. 2002;185(7):905–14.PubMedCrossRefGoogle Scholar
- Schim van der Loeff M, Larke N, Kaye S, Berry N, Ariyoshi K, Alabi A, Van Tienen C, Leglidowicz A, Njie RS, da Silva Z, Jaye A, Vincent T, Rowland Jones S, Aaby P, Jaffar S, Whittle H. Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village. Retrovirology. 2010;19(7):46.CrossRefGoogle Scholar