Medication Adherence and HIV-Associated Neurocognitive Disorders (HAND)
Among persons living with HIV infection, adherence to antiretroviral therapy (ART) and other prescribed medications is the critical factor associated with reductions in morbidity and mortality. As a result, HIV is often considered a chronic illness. There have been several advancements in ART medication development, formulation, and administration that have increased the ease of ART adherence as compared to the early years of the epidemic. Specifically, side effect profiles have improved medication tolerability, and there are newer combination medications that allow for most regimens to be between one to three pills per day. Along with the view that HIV has become a chronic illness, however, is the observation that the number of chronic comorbidities among those with HIV has grown. Thus, pill burden remains high among HIV-infected persons as compared to the general population, although many of the medications are for the treatment of HIV-related conditions...
KeywordsPlacebo Permeability Toxicity Depression Lithium
- Blackstone K, Woods SP, Weber E, Grant I, Moore DJ, the HNRC Group. Memory-based adherence strategies for antiretroviral medication management in HIV: an evaluation of clinical predictors, adherence behavior awareness, and effectiveness. AIDS Behav. 2013b;17(1):74–85.CrossRefPubMedPubMedCentralGoogle Scholar