Antiretroviral Therapy for HIV-Infected Infants, Children, and Adolescents in Resource-Rich Settings
The treatment of HIV-infected infants, children, and adolescents (ICA) mandates the use of a combination of antiretroviral drugs (ARVs) from two or more classes targeting different steps in the HIV life cycle. These classes include nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), integrase strand-transfer inhibitor (INSTI), and attachment/entry inhibitors. There are now 21 Food and Drug Administration (FDA) approved therapeutic agents available for pediatric and adolescent populations ≤17 years of age, with several of those medications available in child-friendly formulations such as suspensions, chewable tablets, and powders. In qualifying adolescents, the use of multiple ARVs combined into a single tablet, also known as single tablet regimens (STRs), may also be considered. The goals of combination antiretroviral therapy (cART), recommendations of when and why to initiate therapy, an...
KeywordsVirologic Failure Tanner Stage Pediatric Clinical Trial Drug Resistance Testing Single Tablet Regimen
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