Initial Antiretroviral Regimens
The first antiretroviral drug regimen used to treat a previously treatment-naïve HIV-infected patient.
Although there are many possible choices for initial antiretroviral therapy (ART) in an HIV-infected patient, only a small subset of the potential options are now recommended in treatment guidelines used in most resource-rich settings. Recommendations are based on a combination of efficacy, safety, tolerability, convenience, and in some cases cost. This review will focus primarily on regimens recommended and used in the United States, where cost has traditionally not been a criterion for guideline selection. However, that may change as less expensive generic drugs become available.
US guidelines include those from the Department of Health and Human Services (DHHS), which are updated approximately once a year (Panel on Antiretroviral Guidelines for Adults and Adolescents 2015), and those from the International Antiviral Society (IAS-USA), updated every 2 years...
KeywordsToxicity Pancreatitis Nucleoside Lamivudine Zidovudine
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