Talaromyces (Penicillium) marneffei and HIV
Talaromyces marneffei, formerly Penicillium marneffei, is a dimorphic fungus. (Samson et al. 2011) T. marneffei infection (TMI) is a common opportunistic infection in HIV-infected patients living in the endemic areas, particularly Southeast Asia, Southern China, and India. However, there have been reports in HIV-infected travelers who have traveled to the endemic areas. (Vanittanakom et al. 2006). The clinical manifestations varied widely from asymptomatic to disseminated infection involving several organs including central nervous system. The epidemiology, clinical manifestations, diagnosis, treatment, and prevention will be described here.
T. marneffei was first isolated in 1956 from the internal organs of bamboo rats (Rhizomys sinensis) in Vietnam (Capponi et al. 1956). The first natural human infection was reported in 1973 in an American missionary who had been living in Southeast Asia (DiSalvo et al. 1973). He suffered from non-Hodgkin lymphoma several...
KeywordsImmune Reconstitution Inflammatory Syndrome Primary Prophylaxis Indirect Fluorescent Antibody Test Oral Itraconazole cART Initiation
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