Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson

Salmonellosis and Other Bacterial Enteric Infections and HIV

  • Christine Wanke
  • Andrew Chandranesan
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_413-1


Enteritis by definition is inflammation of the intestinal wall; this inflammation could be small intestine or large intestine or both. Inflammation may be infectious or noninfectious in origin. Among infectious etiologies, bacterial organisms are most commonly associated with acute infectious enteritis. In this entry enteric bacterial infections in persons living with HIV are discussed as they have been an important cause of morbidity and mortality in this vulnerable population. The rates of gram-negative bacterial infections are at least tenfold higher in persons living with HIV than in the general population. The risk of symptomatic disease varies according to the immune status (as measured by CD4 count) of the host. The greatest risk is in individuals with CD4 count less than 200 cells/mm3. In this entry we aim to provide a concise review of the enteric bacterial pathogens that play a very important role in causing enteritis in the HIV patient population. The first,...


Clostridium Difficile Infection Clostridium Difficile Typhoid Fever Mycotic Aneurysm Diarrheal Illness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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  1. Angulo FJ, Swerdlow DL. Bacterial enteric infections in persons infected with human immunodeficiency virus. Clin Infect Dis. 1995;21(Suppl 1):S84–93.CrossRefPubMedGoogle Scholar
  2. Aragon TJ, et al. Case-control study of shigellosis in San Francisco: the role of sexual transmission and HIV infection. Clin Infect Dis. 2007;44(3):327–34.CrossRefPubMedGoogle Scholar
  3. Arthur G, et al. Trends in bloodstream infections among human immunodeficiency virus-infected adults admitted to a hospital in Nairobi, Kenya, during the last decade. Clin Infect Dis. 2001;33(2):248–56.CrossRefPubMedGoogle Scholar
  4. Benenson S, et al. The risk of vascular infection in adult patients with nontyphi salmonella bacteremia. Am J Med. 2001;110(1):60–3.CrossRefPubMedGoogle Scholar
  5. Bennett JE, et al. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. 8th ed. Philadelphia: Elsevier/Saunders; 2015.Google Scholar
  6. Bennish ML. Potentially lethal complications of Shigellosis. Rev Infect Dis. 1991;13(Suppl 4):S319–24.CrossRefPubMedGoogle Scholar
  7. Bhan MK, Bahl R, Bhatnagar S. Typhoid and paratyphoid fever. Lancet (London, England). 2005;366(9487):749–62.CrossRefGoogle Scholar
  8. Buckle GC, Walker CL, Black RE. Typhoid fever and paratyphoid fever: systematic review to estimate global morbidity and mortality for 2010. J Glob Health. 2012;2(1):010401.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Casado JL, et al. Zidovudine therapy protects against salmonella bacteremia recurrence in human immunodeficiency virus-infected patients. J Infect Dis. 1999;179(6):1553–6.CrossRefPubMedGoogle Scholar
  10. Celum CL, et al. Incidence of salmonellosis in patients with AIDS. J Infect Dis. 1987;156(6):998–1002.CrossRefPubMedGoogle Scholar
  11. Cohen JI, Bartlett JA, Corey GR. Extra-intestinal manifestations of salmonella infections. Medicine. 1987;66(5):349–88.CrossRefPubMedGoogle Scholar
  12. Craib KJ, et al. Rectal gonorrhoea as an independent risk factor for HIV infection in a cohort of homosexual men. Genitourin Med. 1995;71(3):150–4.PubMedPubMedCentralGoogle Scholar
  13. Crump JA, Luby SP, Mintz ED. The global burden of typhoid fever. Bull World Health Organ. 2004;82(5):346–53.PubMedPubMedCentralGoogle Scholar
  14. Gotuzzo E, et al. Association between the acquired immunodeficiency syndrome and infection with salmonella typhi or salmonella pin an endemic typhoid area. Arch Intern Med. 1991;151(2):381–2.CrossRefPubMedGoogle Scholar
  15. Gupta A, et al. Antimicrobial resistance among campylobacter strains, United States, 1997–2001. Emerg Infect Dis. 2004;10(6):1102–9.CrossRefPubMedPubMedCentralGoogle Scholar
  16. Haines CF, et al. Clostridium difficile in a HIV-infected cohort: incidence, risk factors, and clinical outcomes. AIDS (London England). 2013;27(17):2799–807.CrossRefGoogle Scholar
  17. Hoentjen F, Rubin DT. Infectious proctitis: when to suspect it is not inflammatory bowel disease. Dig Dis Sci. 2012;57(2):269–73.CrossRefPubMedGoogle Scholar
  18. Kaakoush NO, et al. Global epidemiology of campylobacter infection. Clin Microbiol Rev. 2015;28(3):687–720.CrossRefPubMedPubMedCentralGoogle Scholar
  19. Keddy KH, et al. Systemic shigellosis in South Africa. Clin Infect Dis. 2012;54(10):1448–54.CrossRefPubMedGoogle Scholar
  20. Khan WA, Griffiths JK, Bennish ML. Gastrointestinal and extra-intestinal manifestations of childhood Shigellosis in a region where all four species of Shigella are endemic. PLoS One. 2013;8(5):e64097.CrossRefPubMedPubMedCentralGoogle Scholar
  21. Klausner JD, Kohn R, Kent C. Etiology of clinical proctitis among men who have sex with men. Clin Infect Dis. 2004;38(2):300–2.CrossRefPubMedGoogle Scholar
  22. Kotloff KL, et al. Global burden of shigella infections: implications for vaccine development and implementation of control strategies. Bull World Health Organ. 1999;77(8):651–66.PubMedPubMedCentralGoogle Scholar
  23. Lynch MF, et al. Typhoid fever in the United States, 1999–2006. JAMA. 2009;302(8):859–65.CrossRefPubMedGoogle Scholar
  24. Majowicz SE, et al. The global burden of nontyphoidal salmonella gastroenteritis. Clin Infect Dis. 2010;50(6):882–9.CrossRefPubMedGoogle Scholar
  25. Man SM. The clinical importance of emerging campylobacter species. Nat Rev Gastroenterol Hepatol. 2011;8(12):669–85.CrossRefPubMedGoogle Scholar
  26. Mayer HB, Wanke CA. Enteroaggregative Escherichia coli as a possible cause of diarrhea in an HIV-infected patient. N Engl J Med. 1995;332(4):273–4.CrossRefPubMedGoogle Scholar
  27. Molina J, et al. Campylobacter infections in HIV-infected patients: clinical and bacteriological features. AIDS (London, England). 1995;9(8):881–5.CrossRefGoogle Scholar
  28. Mughini-Gras L, et al. Campylobacteriosis in returning travellers and potential secondary transmission of exotic strains. Epidemiol Infect. 2014;142(6):1277–88.CrossRefPubMedGoogle Scholar
  29. Niyogi SK. Shigellosis. J Microbiol (Seoul, Korea). 2005;43(2):133–43.Google Scholar
  30. Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the centers for disease control and prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. 2016. Downloaded from http://aidsinfo.nih.gov/guidelines. Accessed 6 Sept 2015.
  31. Rodriguez M, et al. Nontyphoidal salmonella causing focal infections in patients admitted at a Spanish general hospital during an 11-year period (1991–2001). Int J Med Microbiol: IJMM. 2006;296(4–5):211–22.CrossRefPubMedGoogle Scholar
  32. Sanchez TH, et al. Bacterial diarrhea in persons with HIV infection, United States, 1992–2002. Clin Infect Dis. 2005;41(11):1621–7.CrossRefPubMedGoogle Scholar
  33. Stuart BM, Pullen RL. Typhoid: clinical analysis of 360 cases. Arch Intern Med (Chicago, Ill.: 1908). 1946;78(6):629–61.CrossRefGoogle Scholar
  34. Ternhag A, et al. A meta-analysis on the effects of antibiotic treatment on duration of symptoms caused by infection with campylobacter species. Clin Infect Dis. 2007;44(5):696–700.CrossRefPubMedGoogle Scholar
  35. Tindall BJ, et al. Nomenclature and taxonomy of the genus salmonella. Int J Syst Evol Microbiol. 2005;55(Pt 1):521–4.CrossRefPubMedGoogle Scholar
  36. Wanke CA, et al. Enteroaggregative Escherichia coli as a potential cause of diarrheal disease in adults infected with human immunodeficiency virus. J Infect Dis. 1998a;178(1):185–90.CrossRefPubMedGoogle Scholar
  37. Wanke CA, et al. Successful treatment of diarrheal disease associated with enteroaggregative Escherichia coli in adults infected with human immunodeficiency virus. J Infect Dis. 1998b;178(5):1369–72.CrossRefPubMedGoogle Scholar
  38. Wilcox CM, Saag MS. Gastrointestinal complications of HIV infection: changing priorities in the HAART era. Gut. 2008;57(6):861–70.CrossRefPubMedGoogle Scholar

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© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Department of Medicine and Infectious DiseasesTufts University School of MedicineBostonUSA
  2. 2.Infectious DiseasesTufts University School of MedicineBostonUSA