Definition
SLX4, also known as BTBD12 or FANCP, is a Fanconi anemia (FA) complementation group protein. Mutations in SLX4, or any of the additional 18 FA genes, lead to FA, which is a rare, autosomal recessive, genetic disorder. Clinical features of FA patients include congenital physical anomaly, elevated cancer susceptibility, and evolution toward aplastic anemia. FA is the most frequent inherited bone marrow failure syndrome. Collectively, FA proteins compose the FA DNA repair pathway that is involved in the repair of double strand breaks by homologous recombination (HR). SLX4 plays important roles in the final steps of HR by facilitating the resolutions of four-way DNA structures called Holliday junctions (HJ). Indeed, SLX4 is a molecular scaffold to which several proteins with nucleic acid binding and processing activity are recruited, forming the SLX4 complex (SLX4com). Additional reported functions of SLX4com include nucleolytic resolution of HJs, telomere maintenance,...
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Brégnard, C., Guerra, J., Laguette, N. (2015). SLX4 Complex and HIV Replication. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_399-1
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DOI: https://doi.org/10.1007/978-1-4614-9610-6_399-1
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