MX2 and HIV-1 Restriction
The human myxovirus resistance 2 protein (MX2, also named MxB) belongs to the dynamin superfamily of high molecular weight guanosine triphosphatases (GTPases). MX2 is homologous to human MX1 (or MxA) and mouse Mx1 and Mx2 proteins. The Mx genes are inducible by type 1 and type 3 interferons (IFNs). Human MX1 has been long recognized as a potent antiviral factor, capable of preventing replication by numerous RNA viruses, including influenza A and measles viruses, and DNA viruses, such as hepatitis B virus. Human MX2 was recently shown to possess a strong antiviral activity against HIV-1 and other primate lentiviruses. MX2 participates in the type 1 interferon-induced block to HIV-1 infection and acts after reverse transcription, at the level of viral DNA nuclear import and/or integration into the host cell genome.
Detection of viruses and other microbes by cellular sensors in infected cells induces the production of type 1 and type 3 interferons (IFNs). These...
KeywordsHydrolysis Hepatitis Leukemia Influenza Anemia
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