Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson

Autophagy and HIV Infection

  • Laure Papin
  • Coralie F. Daussy
  • Jamal Alfaisal
  • Lucile Espert
  • Fabien P. Blanchet
  • Julià Blanco
  • Martine Biard-Piechaczyk
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_395-1

Definition

Autophagy is a fundamental and highly regulated lysosomal degradation mechanism, dependent on specialized autophagy-related proteins (Atgs) (Mizushima et al. 2011). It can be classified into macroautophagy, microautophagy, and chaperone-mediated autophagy, but only macroautophagy will be described and hereafter referred to as autophagy since it is the major lysosomal route for the turnover of cytoplasmic constituents. It is characterized by the formation of membranes that engulf cytoplasmic material through the formation of autophagic vacuoles, called autophagosomes. These structures fuse with lysosomes to form autolysosomes where the sequestered material is digested by lysosomal hydrolases. Before this degradative step, autophagosomes can also fuse with endosomes to form amphisomes, making a direct connection between the endo-lysosomal and autophagic pathways. This process is highly dynamic, and constituents are continuously recycled through lysosomal transporters toward...

Keywords

Autophagosomal Membrane Autophagy Flux Pathogen Recognition Receptor Specific Protein Complex Atg8 Family 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgment

Laure Papin doctoral fellowship is funded by Sidaction, and Jamal Alfaisal is profiting from the DUNIA BEAM Erasmus Mundus scholarship, funded with the support of the European Commission.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Laure Papin
    • 1
  • Coralie F. Daussy
    • 1
  • Jamal Alfaisal
    • 1
  • Lucile Espert
    • 1
  • Fabien P. Blanchet
    • 1
  • Julià Blanco
    • 2
    • 3
  • Martine Biard-Piechaczyk
    • 1
  1. 1.Centre d’études d’agents Pathogènes et Biotechnologies pour la Santé (CPBS)CNRS–UMRMontpellierFrance
  2. 2.Fundacio irsiCaixaInstitut de Recerca Germans Trias I Pujol (IGTP)BarcelonaSpain
  3. 3.Universitat de Vic (UVIC-UCC)VicSpain