Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson

The Cellular Immune Response to HIV-2 Infection

  • Sophie M. Andrews
  • Glenn Wong
  • Sarah L. Rowland-Jones
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_38-1


T-cells play a central role in both the control and pathogenesis of HIV infection. While T-cell responses against HIV-1 infection have been studied in great detail, much less is known about T-cells in the context of HIV-2. This entry summarizes current understanding of the quantitative and qualitative characteristics of HIV-2-specific CD8+ and CD4+ T-cell responses, highlighting key areas in which they may differ from responses against HIV-1, and the clinical implications of such disparities.


Although HIV-1 and HIV-2 share substantial similarity in terms of genome and life cycle, there are clear epidemiological and prognostic distinctions between them. An important distinguishing feature of infection is the distribution and time to clinical progression (Marlink et al. 1994). In contrast to HIV-1 infection, where the overwhelming majority of treatment-naïve patients develop AIDS within approximately a decade, the outcome of HIV-2 infection follows an unusual...


Dual Infection Undetectable Plasma Viral Load Alternative Protective Mechanism Soluble Antiviral Factor 
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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Sophie M. Andrews
    • 1
  • Glenn Wong
    • 1
  • Sarah L. Rowland-Jones
    • 1
  1. 1.Nuffield Department of MedicineUniversity of OxfordOxfordUK