Definition
Immunogenetics is the study of pathogen and host genetic factors that affect immunological responses leading to abnormal health conditions. The term also encompasses studies of the mechanisms of transmission of those factors from generation to generation in both pathogen and host. Over the past two decades, immunogenetics of infectious diseases has rapidly developed into a diverse field exploiting a range of methodologies to discover new genes and antigens that affect host immune responses. However, despite significant progress in the field and the use of new genetic tools (e.g., next generation sequencing) and study designs (e.g., genome-wide analyses) to tackle the ever-increasing burden of infectious diseases such as the Acquired Immunodeficiency Syndrome (AIDS) caused by the Human Immunodeficiency Virus (HIV), several important questions remain unanswered. For example, what are the immunogenetic variations in humans and in the virus that affect the differential...
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Yindom, LM., Walton, R. (2015). Immunogenetics of HIV-2 Infection. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_33-1
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DOI: https://doi.org/10.1007/978-1-4614-9610-6_33-1
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