Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson


Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_210-1


T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is a member of the T cell/transmembrane, immunoglobulin, and mucin (TIM) gene family of phosphatidylserine-binding proteins (Freeman et al. 2010). It is a type I transmembrane glycoprotein consisting of an N-terminal IgV-like domain and a heavily glycosylated mucin domain, a transmembrane region, and a cytoplasmic tail. Tim-3 plays a role in the regulation of both innate and adaptive immune responses during autoimmunity, cancer, and chronic infections (Han et al. 2013; Zhu et al. 2011). While it has been shown to both negatively and positively regulate innate immune responses, Tim-3 plays a distinct negative regulatory role in regards to T cell responses. During human immunodeficiency virus type 1 (HIV) infection, Tim-3 marks dysfunctional T cells during chronic stages of infection and acts to dampen responses to viral antigen, contributing to the “exhausted” state of the immune system and lack of viral...


Human Immunodeficiency Virus Natural Killer Cell Human Immunodeficiency Virus Infection Adaptive Immune Cell Cell Exhaustion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of ImmunologyUniversity of TorontoTorontoCanada
  2. 2.Department of MedicineUniversity of TorontoTorontoCanada
  3. 3.Keenan Research Centre for Biomedical Science of St. Michael’s HospitalTorontoCanada