Role of Regulatory T Cells During HIV Infection
Human immunodeficiency virus (HIV) causes a gradual loss of immune competence, leading to acquired immunodeficiency syndrome (AIDS). HIV-associated defects in cell-mediated immunity (CMI) are of particular importance, as these impairments lead to poor control of HIV replication and of other pathogens whose clearance depends on CMI. Importantly, a number of immune deficits caused by HIV infection can be partially restored in vitro, suggesting the existence of active regulatory mechanisms. Several mechanisms are involved in the regulation of the immune system; among these is the pivotal role of regulatory T cells (Treg), a subset of CD4+T cells, which has been recognized for several years. In addition to their role in controlling peripheral tolerance, Treg promote the establishment of persistent infections (viral, bacterial, parasitic, and fungal). Treg may thus contribute to inefficient CMI during chronic HIV infection. However, Treg may also play a beneficial role, because...
KeywordsHuman Immunodeficiency Virus Human Immunodeficiency Virus Infection Rhesus Macaque Human Immunodeficiency Virus Patient Human Immunodeficiency Virus Replication
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