Post-treatment controllers (PTC) are HIV-infected patients able to maintain a durable control of viremia at undetectable levels after interruption of antiretroviral treatment. Differently from natural HIV “elite” controllers (HIC), post-treatment controllers require therapeutic intervention to first reach undetectable viral loads. Post-treatment controllers still carry infected cells and, thus, are not cured but considered to be in sustained remission of HIV infection. These patients have also been termed “secondary controllers.”
The introduction of combination antiretroviral treatment (cART) as the standard of care for HIV-infected individuals changed the face of the AIDS epidemics. cART has drastically reduced mortality and morbidities of HIV-infected patients (Boyd 2009) and has also proven its value as a prevention tool by decreasing the risk of transmission (Cohen et al. 2011). A few years after cART was implemented, it was hypothesized that the perfectly...
- Ananworanich J, Vandergeeten C, Chomchey N, et al. Early ART intervention restricts the seeding of the HIV reservoir in long-lived central memory CD4 T cells. In: 20th conference on retroviruses and opportunistic infections, Atlanta, 3–6 Mar 2013. Abstract 47.Google Scholar
- Luzuriaga K, et al. HIV type 1 (HIV-1) proviral reservoirs decay continuously under sustained virologic control in HIV-1-infected children who received early treatment. J Infect Dis. 2014. doi:10.1093/infdis/jiu297.Google Scholar