Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson

Post-treatment Controllers

  • Asier Sáez-Cirión
  • Laurent Hocqueloux
  • Christine Rouzioux
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_201-1

Definition

Post-treatment controllers (PTC) are HIV-infected patients able to maintain a durable control of viremia at undetectable levels after interruption of antiretroviral treatment. Differently from natural HIV “elite” controllers (HIC), post-treatment controllers require therapeutic intervention to first reach undetectable viral loads. Post-treatment controllers still carry infected cells and, thus, are not cured but considered to be in sustained remission of HIV infection. These patients have also been termed “secondary controllers.”

Introduction

The introduction of combination antiretroviral treatment (cART) as the standard of care for HIV-infected individuals changed the face of the AIDS epidemics. cART has drastically reduced mortality and morbidities of HIV-infected patients (Boyd 2009) and has also proven its value as a prevention tool by decreasing the risk of transmission (Cohen et al. 2011). A few years after cART was implemented, it was hypothesized that the perfectly...

Keywords

Buzon 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Asier Sáez-Cirión
    • 1
  • Laurent Hocqueloux
    • 2
  • Christine Rouzioux
    • 3
    • 4
  1. 1.Institut PasteurUnité de Régulation des Infections RétroviralesParisFrance
  2. 2.CHR d’Orléans- La SourceService des Maladies Infectieuses et TropicalesOrléansFrance
  3. 3.Hopital Necker, Laboratoire de VirologieUniversité Paris DescartesParisFrance
  4. 4.Université Paris DescartesParisFrance