Encyclopedia of Medical Immunology

2014 Edition
| Editors: Ian R. Mackay, Noel R. Rose, Dennis K. Ledford, Richard F. Lockey

Hypereosinophilic Syndromes

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9194-1_91

Hypereosinophilic syndromes (HESs) is a different group of rare disorders defined by the presence of persistent peripheral blood eosinophilia (1,500 eosinophils/μl in blood), in the absence of any obvious reason of eosinophilia, such as parasitic or viral infections, allergic diseases, drug- or chemical-induced eosinophilia, hypoadrenalism, or nonhematological malignancies (Simon et al. 2010). HESs include platelet-derived growth factor receptor alpha (PDGFRA)–associated HES, lymphocytic variant HES (L-HES), familial hypereosinophilia, Churg-Strauss syndrome (CSS), organ-restricted eosinophilic disorders, and others (Simon et al. 2010). There are two categories for these difficult to diagnose disease: First, the cause might be due to increased production of cytokines-mediators that boost the differentiation and viability of eosinophils. These HES types are considered as “extrinsic eosinophilic disorders.” The second major group of hypereosinophilic diseases is due to mutation-mediated...

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute of PharmacologyUniversity of BernBernSwitzerland