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IgE Receptor

  • Reference work entry
  • First Online:
Encyclopedia of Medical Immunology

  • 165 Accesses

Synonyms

High affinity IgE receptor/FCeRI; Low affinity IgE receptor/FcεRIIb/CD23

Definition

Cell surface receptor that specifically binds IgE.

IgE Receptors

There are two Fc receptors that specifically bind IgE through interaction with its Fc region: the high-affinity IgE receptor FCεRI and the low-affinity IgE receptor FCεRII, also known as CD23. Furthermore a protein called galectin-3 which is primarily secreted from macrophages can bind IgE as well as FcεRI. Galectin 3 is a 30 kDa galactoside-binding lectin that can form pentamers in complex with oligosaccharides which are present on IgE and FcεRI. As a result, galectin-3 can activate mast cells and basophils by cross-linking FcεRI directly or indirectly through receptor-bound IgE molecules (Gould and Sutton 2008).

High-Affinity IgE Receptor

FcεRI is expressed on mast cells, basophils, epidermal Langerhans’ cells, dendritic cells (DC), monocytes, and, under certain conditions, intestinal epithelial cells. The human FcεRI can be...

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Author information

Authors and Affiliations

  1. Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Oberestrasse 22, CH-7270, Davos Platz, Davos, Switzerland

    Willem van de Veen

Authors
  1. Willem van de Veen
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Corresponding author

Correspondence to Willem van de Veen .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, James A. Haley Veterans' Hospital, Tampa, FL, USA

    Dennis K. Ledford

  4. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, James A. Haley Veterans' Hospital, Tampa, FL, USA

    Richard F. Lockey

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© 2014 Springer-Verlag Berlin Heidelberg

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van de Veen, W. (2014). IgE Receptor. In: Mackay, I.R., Rose, N.R., Ledford, D.K., Lockey, R.F. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9194-1_75

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  • DOI: https://doi.org/10.1007/978-1-4614-9194-1_75

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-9193-4

  • Online ISBN: 978-1-4614-9194-1

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