Encyclopedia of Medical Immunology

2014 Edition
| Editors: Ian R. Mackay, Noel R. Rose, Dennis K. Ledford, Richard F. Lockey

Topical Corticosteroids

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9194-1_245

Synonyms

Topical glucocorticosteroids; Topical steroids

Definition

Topical glucocorticoids are commonly used in the treatment of rashes caused by allergic reactions, eczema, dermatitis, and other corticosteroid-responsive dermatoses. Topical corticosteroids have anti-inflammatory, antipruritic, and vasoconstrictive properties. All preparations have similar mechanisms of action but differ in the nature of their base and potency, thus allowing for a range of applications depending on the anatomic location and severity of the disease to be treated.

Mechanism of Action

The mechanism of action of glucocorticoids involves reducing the cellular inflammatory response. Mechanistically, the glucocorticoid (GC) binds to the glucocorticoid receptor (GR) complex (with several heat shock proteins, and other proteins), located within the cytoplasm of the target cell (Adcock 2001). The bound GC-GR complex is then translocated to the nucleus and in the nucleus, and interacts with GC responsive...

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Semyon Aminov
    • 1
  • Patrick J. McKeonII
    • 1
  • Shyam Gelot
    • 2
  1. 1.University of South Florida College of PharmacyTampaUSA
  2. 2.Department of Pharmacotherapeutics and Clinical ResearchUniversity of South Florida, College of PharmacyTampaUSA