Encyclopedia of Medical Immunology

2014 Edition
| Editors: Ian R. Mackay, Noel R. Rose, Dennis K. Ledford, Richard F. Lockey

Honeybee Allergy

  • Michael S. Tankersley
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9194-1_226

Synonyms

Apis mellifera

Introduction

As the primary pollinators in the world, bees have global significance. Honeybee (Apis mellifera) hives can be found in either the hives of beekeepers or in the case of feral (wild) honeybees in tree hollows, fallen logs, or buildings. Much has been made over the last few decades of Africanized honeybees which consist of hybrids from interbreeding of domestic honeybees and African honeybees from South America. Africanized honeybees are more aggressive species than domestic honeybees and may attack in swarms (Alaux et al. 2009). Though not pathognomonic for honeybees, upon stinging the honeybee typically leaves its barbed stinger and attached venom sac at the sting site. A sting was originally thought to deliver approximately 50 mcg of honeybee venom though subsequent evaluation has shown this to be variable.

Honeybee Entomology

The honeybee (Apis mellifera) includes the European honeybee (subspecies A. mellifera ligustica) and the African honeybee...

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References

  1. Alaux C, Sinha S, Hasadsri L, Hunt G, Guzman-Novoa E, DeGrandi-Hoffman G, Uribe-Rubio JL, et al. Honey bee aggression supports a link between gene regulation and behavioral evolution. PNAS. 2009;106:15400–5.PubMedCrossRefPubMedCentralGoogle Scholar
  2. Baenkler PHW, Meuber-Storm S, Eger G. Continuous immunotherapy for hymenoptera venom allergy using six month intervals. Allergol Immunopathol. 2005;33:7–14.CrossRefGoogle Scholar
  3. Bloch G. The social clock of the honeybee. J Biol Rythms. 2010;25:307–17.CrossRefGoogle Scholar
  4. de Graaf DC, Aerts M, Danneels E, Devreese B. Bee, wasp and ant venomics pave the way for a component-resolved diagnosis of sting allergy. J Proteomics. 2009;72:145–54.PubMedCrossRefGoogle Scholar
  5. Georgieva D, Greunke K, Betzel C. Three-dimensional model of the honeybee venom allergen Api m 7: structural and functional insights. Mol Biosyst. 2010;6:1056–60.PubMedCrossRefGoogle Scholar
  6. Goldberg A, Confino-Cohen R. Maintenance venom immunotherapy administered at 3-month intervals is both safe and efficacious. J Allergy Clin Immunol. 2001;107:902–6.PubMedCrossRefGoogle Scholar
  7. Goldberg A, Reisman RE. Prolonged interval maintenance venom immunotherapy. Ann Allergy. 1988;61:177–9.PubMedGoogle Scholar
  8. Goldberg A, Confino-Cohen R, Mekori YA. Deliberate bee sting challenge of patients receiving maintenance venom immunotherapy at 3-month intervals. J Allergy Clin Immunol. 1994;93:997–1001.PubMedCrossRefGoogle Scholar
  9. Golden DBK, Moffitt J, Nicklas RA. Stinging insect hypersensitivity: a practice parameter update 2011. J Allergy Clin Immunol. 2011;127:852–4.PubMedCrossRefGoogle Scholar
  10. Kochuyt AM, Stevens EAM. Safety and efficacy of a 12-week maintenance interval in patients treated with Hymenoptera venom immunotherapy. Clin Exp Allergy. 1994;24:35–41.PubMedCrossRefGoogle Scholar
  11. Muller U, Helbling A, Berchtold E. Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safety. J Allergy Clin Immunol. 1992;89:529–35.PubMedCrossRefGoogle Scholar
  12. Muller UR, Johansen N, Petersen AB, Fromberg-Nielsen J, Haeberli G. Hymenoptera venom allergy: analysis of double positivity to honey bee and Vespula venom by estimation of IgE antibodies to species-specific major allergens Api m1 and Ves v5. Allergy. 2009;64:543–8.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Allergy and Immunology Division, Department of MedicineWilford Hall Medical CenterSan AntonioUSA