Mitochondrial Protein Import in Malaria Parasites
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Mitochondria are essential organelles for malaria parasites and their hosts. Proteins from all four major mitochondrial compartments are predominantly synthesized in the cytosol. The biogenesis of mitochondria therefore requires (i) a variety of specific substrate features that are utilized for mitochondrial targeting and (ii) efficient and selective compartment-specific machineries for the recognition, sorting, processing, and folding of these substrates.
KeywordsMitochondrial Membrane Malaria Parasite Outer Mitochondrial Membrane Transmembrane Segment Intermembrane Space
- Wallace DC, Youle RJ, editors. Mitochondria. New York: Cold Spring Harbor Laboratory; 2013.Google Scholar