Mitochondrial Protein Import in Malaria Parasites
Mitochondria are essential organelles for malaria parasites and their hosts. Proteins from all four major mitochondrial compartments are predominantly synthesized in the cytosol. The biogenesis of mitochondria therefore requires (i) a variety of specific substrate features that are utilized for mitochondrial targeting and (ii) efficient and selective compartment-specific machineries for the recognition, sorting, processing, and folding of these substrates.
- Wallace DC, Youle RJ, editors. Mitochondria. New York: Cold Spring Harbor Laboratory; 2013.Google Scholar