Encyclopedia of Malaria

Editors: Peter G. Kremsner, Sanjeev Krishna

Mitochondrial Protein Import in Malaria Parasites

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-8757-9_95-1

Definition

Mitochondria are essential organelles for malaria parasites and their hosts. Proteins from all four major mitochondrial compartments are predominantly synthesized in the cytosol. The biogenesis of mitochondria therefore requires (i) a variety of specific substrate features that are utilized for mitochondrial targeting and (ii) efficient and selective compartment-specific machineries for the recognition, sorting, processing, and folding of these substrates.

Introduction

In most eukaryotes, mitochondria play a crucial role in numerous cellular processes including oxidative phosphorylation (yielding ATP) as well as the metabolism of lipids, amino acids, pyrimidines, and iron-sulfur clusters. Furthermore, in a variety of eukaryotes, mitochondrial processes even determine or regulate the fate of the whole cell during programmed cell death (Wallace and Youle 2013). Even though mitochondria contain their own genome as well as transcription and translation machineries, most...
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Infectiology/ParasitologyHeidelberg UniversityHeidelbergGermany