Cytokines and Some of Their Effector Mechanisms in Cerebral Malaria Pathogenesis
Comorbidities: intercurrent or concomitant diseases, infectious or not; Erythrocyte: red blood cell; Immunomodulator: able to modulate immune responses; Leucocyte: white blood cell; Membrane vesiculation: membrane budding; Neuroexcitotoxin: toxic excitatory neuromediator; Pathognomonic: specific of a given disease
Cytokines, small molecules that regulate the immune response, are also capable of driving immunopathological processes. These include some of the severe complications of malaria, in particular involvement of the brain, known as cerebral malaria. To exert their deleterious effects, cytokines need to implicate a vast array of pathogenic effector mechanisms.
The pathophysiology of infectious diseases has been widely investigated. Involvement of the cells and soluble mediators of the immune system has been universally recognized as contributing to the complications of viral, bacterial, fungal, and many parasitic infections. It would be...
KeywordsMalaria Infection Severe Malaria Cerebral Malaria Kynurenine Pathway Severe Malarial Anemia
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