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Physiopathology of Malaria During Pregnancy: Adhesion and Sequestration Phenotypes of Malaria Infection

  • Living reference work entry
  • First Online:
Encyclopedia of Malaria

  • 292 Accesses

Synonyms

Cytoadhesion of Plasmodium in pregnant women; Gestational malaria; Malaria in pregnancy

Definition

Cytoadhesion in malaria is the ability of the parasite to adhere to endothelial cell receptors. Cytoadhesion during pregnancy may occur at the placenta where the Plasmodium parasites can adhere to CSA receptors.

Introduction

Adult women living in a malaria-endemic area are more susceptible to malaria symptomatic disease during the first pregnancy. Although severe malaria is more common during the first years in life, malaria during pregnancy, especially in the first pregnancy, is a peculiar case. Malaria in pregnancy can cause severe disease to the mother and to the fetus. Severe maternal anemia and low birth weight babies are some consequences of malaria in pregnancy (Brabin 1983).

The sequestration of the parasite in the placenta is a mechanism that protects the parasite from being eliminated by the spleen. On the other hand, for the host, the sequestration of infected...

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Authors and Affiliations

  1. Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas, Rua Monteiro Lobato, 255, CEP 13083-862, Campinas, SP, Brazil

    Fabio Trindade Maranhão Costa & Letusa Albrecht

  2. Institute Carlos Chagas, FIOCRUZ-PARANÁ, Rua Algacyr Munhoz Mader, 3775, 81350-010, PR, Brazil

    Letusa Albrecht

  3. PRES Sorbonne Paris Cité, Faculté de Pharmacie, Université Paris Descartes, Paris, France

    Nicaise Tuikue Ndam

  4. Mother and Child Health in the Tropics, Faculté de Pharmacie, Institut de Recherche pour le Développement (IRD), UMR216-MERIT, Université Paris Descartes, 4 avenue de l’Observatoire, 75270 cedex 06, Paris, France

    Nicaise Tuikue Ndam

Authors
  1. Fabio Trindade Maranhão Costa
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  2. Letusa Albrecht
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  3. Nicaise Tuikue Ndam
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Corresponding authors

Correspondence to Fabio Trindade Maranhão Costa or Nicaise Tuikue Ndam .

Editor information

Editors and Affiliations

  1. Heswall, United Kingdom

    Marcel Hommel

  2. Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany

    Peter G. Kremsner

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Costa, F.T.M., Albrecht, L., Ndam, N.T. (2015). Physiopathology of Malaria During Pregnancy: Adhesion and Sequestration Phenotypes of Malaria Infection. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_66-1

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  • DOI: https://doi.org/10.1007/978-1-4614-8757-9_66-1

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  • Online ISBN: 978-1-4614-8757-9

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