Encyclopedia of Malaria

Living Edition
| Editors: Peter G. Kremsner, Sanjeev Krishna

Physiopathology of Malaria During Pregnancy: Pregnancy-Specific Malaria Immune Responses

  • Alfredo Mayor
  • Samad A. Ibitokou
  • Philippe Deloron
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-8757-9_64-1



Identification of immune responses that can provide protection against the adverse effects of malaria in pregnancy (i.e., low birth weight, stillbirth, and maternal anemia) is essential for the rational development of new malaria control tools. Protective immunity has been suggested to be mediated by antibodies against VAR2CSA, the variant antigen expressed on the surface of Plasmodium falciparum-infected erythrocytes that binds chondroitin sulfate A (CSA) to enable sequestration in the placenta.

Pregnancy-associated malaria (PAM) due to infection with P. falciparum is a major disease that affects birth outcome in sub-Saharan Africa, causing up to 363,000 infant deaths annually (Guyatt and Snow 2004). WHO estimates that 50 million pregnant women per year are exposed to malaria (WHO 2012). In contrast to adults living in endemic areas who develop immunity...


Pregnant Woman Malaria Transmission Malaria Infection Infected Erythrocyte Maternal Anemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Alfredo Mayor
    • 1
    • 2
  • Samad A. Ibitokou
    • 3
    • 4
    • 6
  • Philippe Deloron
    • 4
    • 5
  1. 1.ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de BarcelonaBarcelonaSpain
  2. 2.Centro De Investigação Em Saúde Da Manhiça (Cism)MaputoMozambique
  3. 3.Faculté des Sciences de la SantéCentre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l’Enfance (CERPAGE), Université d’Abomey-CalaviCotonouBenin
  4. 4.Institut de Recherche pour le Développement (IRD), UMR216ParisFrance
  5. 5.Faculty of PharmacyPRES Sorbonne Paris Cité, Université Paris DescartesParisFrance
  6. 6.Department of Internal Medicine, Division of Infectious DiseaseUniversity of Texas Medical BranchGalvestonUSA