Druggable Biochemical Targets: Facts and Fancies
Biochemical target: macromolecule (protein or non-protein) that is (i) vital for the malaria parasite, or critical for its interaction and propagation within the human host, and (ii) functionally blocked by a drug.
What Is a Biochemical Target?
In medical sciences, the notion of target is versatile enough to be used in various, sometimes overlapping, meanings, qualifying any biological object and/or phenomenon, one aims to act on as part of a therapy. It follows that a targetcan be defined at different scales, as a phenotype expressed by the patient (e.g., symptoms including fever, weakness, and pain), a biological process causing the disease (e.g., a vital metabolic pathway in the pathogen or a molecular mechanism involved in the infection), a subcellular structure (e.g., a vital organelle of the pathogen), a protein (e.g., a vital enzyme of a pathogen), a protein domain (e.g., a “pocket” at the surface of a protein, where a drug can dock;...
KeywordsAntimalarial Drug Dihydrofolate Reductase Sesquiterpene Lactone Cinchona Alkaloid Drug Development Program
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