Encyclopedia of Malaria

Living Edition
| Editors: Peter G. Kremsner, Sanjeev Krishna

Druggable Biochemical Targets: Facts and Fancies

  • Eric Maréchal
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-8757-9_56-1



Biochemical target: macromolecule (protein or non-protein) that is (i) vital for the malaria parasite, or critical for its interaction and propagation within the human host, and (ii) functionally blocked by a drug.

What Is a Biochemical Target?

In medical sciences, the notion of target is versatile enough to be used in various, sometimes overlapping, meanings, qualifying any biological object and/or phenomenon, one aims to act on as part of a therapy. It follows that a targetcan be defined at different scales, as a phenotype expressed by the patient (e.g., symptoms including fever, weakness, and pain), a biological process causing the disease (e.g., a vital metabolic pathway in the pathogen or a molecular mechanism involved in the infection), a subcellular structure (e.g., a vital organelle of the pathogen), a protein (e.g., a vital enzyme of a pathogen), a protein domain (e.g., a “pocket” at the surface of a protein, where a drug can dock;...


Antimalarial Drug Dihydrofolate Reductase Sesquiterpene Lactone Cinchona Alkaloid Drug Development Program 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Laboratoire de Physiologie Cellulaire VégétaleUnité mixte de recherche 5168 CNRS – CEA – UnivGrenobleFrance