Encyclopedia of Malaria

Living Edition
| Editors: Peter G. Kremsner, Sanjeev Krishna

Druggable Biochemical Targets: Facts and Fancies

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-8757-9_56-1

Synonyms

Definition

Biochemical target: macromolecule (protein or non-protein) that is (i) vital for the malaria parasite, or critical for its interaction and propagation within the human host, and (ii) functionally blocked by a drug.

What Is a Biochemical Target?

In medical sciences, the notion of target is versatile enough to be used in various, sometimes overlapping, meanings, qualifying any biological object and/or phenomenon, one aims to act on as part of a therapy. It follows that a targetcan be defined at different scales, as a phenotype expressed by the patient (e.g., symptoms including fever, weakness, and pain), a biological process causing the disease (e.g., a vital metabolic pathway in the pathogen or a molecular mechanism involved in the infection), a subcellular structure (e.g., a vital organelle of the pathogen), a protein (e.g., a vital enzyme of a pathogen), a protein domain (e.g., a “pocket” at the surface of a protein, where a drug can dock;...

Keywords

Folate Plasmodium Quinoline Chloroquine Dock 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Laboratoire de Physiologie Cellulaire VégétaleUnité mixte de recherche 5168 CNRS – CEA – UnivGrenobleFrance