Pentose Phosphate Pathway
The pentose phosphate pathway (PPP) active in the host red blood cell and in the malaria parasite is complementary and alternative to glycolysis. PPP is the main producer of NADPH and pentose phosphates. NADPH regenerates reduced glutathione and reduced thioredoxin that protect hemoglobin and essential thiol groups from oxidation. Pentose phosphates are utilized for nucleoside, DNA, and RNA synthesis. The first, NADPH-producing reaction of PPP is catalyzed by glucose-6-phosphate dehydrogenase (G6PD). Mutations leading to G6PD deficiency are very frequent in malaric or ex-malaric regions, due to its protection against malaria. The parasite G6PD is very different from the human enzyme and as such a promising drug target candidate.
KeywordsPentose Phosphate Pathway Severe Malaria Cerebral Malaria G6PD Deficiency G6PD Activity
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