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Rab Proteins

  • Living reference work entry
  • First Online:
Encyclopedia of Malaria

  • 308 Accesses

Synonyms

GAP – GTPase-activating protein; GDP – guanosine diphosphate; GEF – GTP exchange factor; GTP – guanosine triphosphate; Inner membrane complex – IMC; MLC1 – myosin light chain 1; MTIP – myosin tail-interacting protein; Myosin A – MyoA; rabGDI – Rab GDP dissociation inhibitor

Definition

Importantly, Plasmodium parasites are able to survive inside erythrocytes that are deficient in de novo protein and lipid biosynthesis and, furthermore, are meant to lack secretory, endocytic, and phagocytic capacities. In spite of this, the parasite manages to secrete and take up substances across the three membrane barriers, and to do so it must establish novel permeation and transport pathways for small solutes and macromolecules (Spielmann and Gilberger 2010; see also “Protein Export”and “Protein Traffic”). The infection of human erythrocytes by Plasmodiumposes, therefore, not only a major public health problem but also a cellular microbiology problem of great complexity. To insure its...

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Authors and Affiliations

  1. Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, Departement d’Immunologie, Inflammation et Infection, Cochin Institute, Faculté de Médecine, Université Paris Descartes - Sorbonne Paris Cite, Institut National de Recherche Médicale U1016, Centre National Recherche Scientifique UMR 8104, Paris, France

    Fathia Ben-Rached & Gordon Langley

Authors
  1. Fathia Ben-Rached
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  2. Gordon Langley
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Correspondence to Fathia Ben-Rached .

Editor information

Editors and Affiliations

  1. Heswall, United Kingdom

    Marcel Hommel

  2. Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany

    Peter G. Kremsner

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Ben-Rached, F., Langley, G. (2013). Rab Proteins. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_36-1

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  • DOI: https://doi.org/10.1007/978-1-4614-8757-9_36-1

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