Encyclopedia of Malaria

Living Edition
| Editors: Peter G. Kremsner, Sanjeev Krishna

Glyoxalase Systems in Malaria Parasites

  • Marcel DeponteEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-8757-9_17-1



The glyoxalase system consists of glutathione and two enzymes that catalyze the conversion of 2-oxoaldehydes to 2-hydroxycarboxylic acids. For example, the cytosolic glyoxalase systems of malaria parasites and their hosts convert harmful glycolysis-derived methylglyoxal to d-lactic acid. Moreover, the host-parasite unit comprises additional glyoxalase isoforms with peculiar properties suggesting other, yet uncharacterized, physiological functions.


According to current theories the glyoxalase system is a metabolic adaptation to reactive 2-oxoaldehydes (2-OAs), which are formed as by-products during glycolysis and other metabolic pathways. Electrophilic 2-OAs are harmful because of their ability to react with physiological nucleophiles resulting in modified proteins and nucleic acids. Such modified biomolecules are summarized as advanced glycation endproducts...


Malaria Parasite Glycolytic Flux Glutamate Residue Glycation Endproducts Glyoxalase System 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Infectiology/ParasitologyHeidelberg UniversityHeidelbergGermany