Glyoxalase Systems in Malaria Parasites
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The glyoxalase system consists of glutathione and two enzymes that catalyze the conversion of 2-oxoaldehydes to 2-hydroxycarboxylic acids. For example, the cytosolic glyoxalase systems of malaria parasites and their hosts convert harmful glycolysis-derived methylglyoxal to d-lactic acid. Moreover, the host-parasite unit comprises additional glyoxalase isoforms with peculiar properties suggesting other, yet uncharacterized, physiological functions.