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Introduction
The central purpose of the immune system is to recognize danger and protect us from infections and cancers. The immune system is an integral part of many other organ systems, including the skin, gastrointestinal tract, and respiratory tract, with roles in wound healing, mucosal immunity, and protection against inhaled pathogens. A complex network of cells, cytokines, antibodies, and proteins are intricately orchestrated in the development of an immune response against infection and in the resolution of the immune response. Due to the complexity of the immune system, there are often “backup” defense networks in place, such that minor defects of the immune system may not cause a great susceptibility to infections. However, defects in critical genes cause significantly increased susceptibility to recurrent, severe, or unusual infections, often accompanied by immune dysregulation or autoimmunity. The recognition of primary immunodeficiency...
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Perez, E.E. (2020). Clinical Presentation of Immunodeficiency, Primary Immunodeficiency. In: Orange, J.S., Chinen, J. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8678-7_69
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DOI: https://doi.org/10.1007/978-1-4614-8678-7_69
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