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Common Variable Immunodeficiency (CVID)

  • Reference work entry
  • First Online:
Encyclopedia of Medical Immunology

  • 14 Accesses

Synonyms

CVID

Definition

Common variable immunodeficiency (CVID) is a heterogeneous clinical-immunological entity that represents the most common form of human primary immunodeficiency (Bonilla et al. 2016). There are several definitions of CVID. The most frequently used is the definition by the ESID/PAGID from 1999 (Conley et al. 1999) and more recently the definition by the ESID registry (Seidel et al. 2019). Alternative suggestions have been made by the group of R. Ameratunga (Ameratunga et al. 2016).

Definition according to ESID/PAGID criteria 1999 (Conley et al. 1999).

Probable: Male or female patient who has a marked decrease of IgG (at least 2 SD below the mean for age) and a marked decrease in either IgM or IgA and fulfills all of the following criteria:

  1. (1)

    Onset of immunodeficiency at greater than 2 years of age.

  2. (2)

    Absent isohemagglutinins and/or poor response to vaccines.

  3. (3)

    Defined causes of hypogammaglobulinemia have been excluded (incl. drug induced...

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Author information

Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology and Center for Chronic Immunodeficiency, University Medical Center and University of Freiburg, Freiburg, Germany

    Klaus Warnatz

  2. Department of Clinical Immunology, Hôpital Saint-Louis, Paris, France

    Eric Oksenhendler

Authors
  1. Klaus Warnatz
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  2. Eric Oksenhendler
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Corresponding author

Correspondence to Klaus Warnatz .

Editor information

Editors and Affiliations

  1. Department of Pediatrics, Columbia University Vagelos, College of Physicians and Surgeons, NewYork-Presbyterian Morgan, Stanley Children’s Hospital, New York, NY, USA

    Jordan Scott Orange

  2. Division of Allergy and Immunology, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, The Woodlands, TX, USA

    Javier Chinen

Section Editor information

  1. Center for Chronic Immunodeficiency, University Medical Center and University of Freiburg, Freiburg, Germany

    Klaus Warnatz

  2. UMC Utrecht, Utrecht, The Netherlands

    Joris M. van Montfrans

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Warnatz, K., Oksenhendler, E. (2020). Common Variable Immunodeficiency (CVID). In: Orange, J.S., Chinen, J. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8678-7_22

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