Prokinetic Agents with Enteral Nutrition

  • Ron R. Neyens
  • Melissa L. Hill
  • Michelle R. Huber
  • Julio A. Chalela
Living reference work entry


Early and adequate enteral nutrition is associated with reduced morbidity and mortality in the critically ill patient, but due to high rates of enteral intolerance and concerns for aspiration and pneumonia, many patients do not receive it in a timely fashion. Although not definitively proven to reduce the rates of aspiration and pneumonia, prokinetic therapy has a modest benefit in improving enteral tolerance and delivery of enteral nutrition. Therapeutic selection is dependent upon the clinical scenario, patient’s comorbidities, drug-drug interactions, and end-organ function. Patients deemed to be at high risk of intolerance, prokinetic adverse events, or failed prokinetic therapy may benefit from placement of a post-pyloric tube.


Gastric Emptying Enteral Nutrition Prokinetic Agent Gastric Residual Volume Colonic Pseudoobstruction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations


Serotonergic agonist


Acute colonic pseudoobstruction


American Society for Parenteral and Enteral Nutrition




Creatinine clearance


Cytochrome P450


Dopaminergic antagonist


Extrapyramidal symptoms


European Society of Parenteral and Enteral Nutrition


Gastric residual volume


Intensive care unit




Traumatic brain injury


Ventilator-associated pneumonia


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Ron R. Neyens
    • 1
  • Melissa L. Hill
    • 2
  • Michelle R. Huber
    • 1
  • Julio A. Chalela
    • 2
  1. 1.Department of PharmacyMedical University of South CarolinaCharlestonUSA
  2. 2.Department of NeurosciencesCollege of Medicine, Medical University of South CarolinaCharlestonUSA

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