Vitamin C, Extremity Trauma, and Surgery

  • Naohiro Shibuya
  • Monica R. Agarwal
  • Daniel C. Jupiter
Living reference work entry


Complex regional pain syndrome (CRPS) is a devastating condition often seen after extremity injury and surgery. Prevention of this pathology is attractive not only to patients but also to healthcare providers, as the management of this condition when it becomes chronic can be difficult. One of the safest and efficacious regimens which can be used to prevent occurrence of CRPS in patients with extremity surgery and trauma is the use of daily, high-dose vitamin C for several weeks. A daily dose of more than 500 mg has been recommended by clinical studies, a systematic review with meta-analysis, and a multidisciplinary guideline. Efficacy and safety of vitamin C used to prevent CRPS are discussed.


Complex Regional Pain Syndrome Wrist Fracture Reflex Sympathetic Dystrophy Oral Vitamin Complementary Alternative Medicine 
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List of Abbreviations


Complex regional pain syndrome


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Copyright information

© Springer Science and Business Media New York (outside the USA) 2014

Authors and Affiliations

  • Naohiro Shibuya
    • 1
    • 2
    • 3
  • Monica R. Agarwal
    • 1
    • 3
  • Daniel C. Jupiter
    • 4
  1. 1.Department of SurgeryTexas A&M University Health Science Center, College of MedicineBryanUSA
  2. 2.Baylor Scott and White Health Care SystemTempleUSA
  3. 3.Central Texas VA Health Care SystemTempleUSA
  4. 4.Department of Preventive Medicine and Community HealthUniversity of Texas Medical BranchGalvestoneUSA

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