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Enteral Supplementation of Palm Vitamin E and Alpha-Tocopherol: Pre-clinical Aspects

  • Mohd Fahami Nur Azlina
  • Haji Mohd Saad Qodriyah
  • Yusof Kamisah
Reference work entry

Abstract

The occurrence of acute gastrointestinal bleeding had been described in 6 % to 100 % in critically ill patients. The morbidity and mortality of patients with critical illnesses are positively correlated with the degree of oxidative stress. Therefore, the administration of antioxidants such as vitamin E seems to be a reasonable therapeutic approach. However, there is conflicting evidence about antioxidant supplementation. This chapter will reveal the scientific evidence of enteral supplementation of vitamin E in the forms of tocotrienol, tocotrienol-rich fraction, and α-tocopherol in animal models of stress. These models mimic the stress endured by critically ill patients in a clinical setting. The positive outcomes of enteral feeding with vitamin E in reducing the occurrence of stress-induced ulcers are discussed in this chapter. Evidences showing vitamin E’s effects are not just related to its ability to reduce gastric aggressive factors and to maintain gastric protective factors but also on its effects on stress hormones and catecholamines.

Keywords

Gastric Mucosa Enteral Nutrition Gastric Lesion Gastric Motility Gastric Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations

ACTH

Adrenocorticotropic hormone

CAT

Catalase

COX

Cyclooxygenase enzyme

EGF

Epidermal growth factor

GPx

Glutathione peroxidase

GSH

Reduced glutathione

GSSG

Oxidized glutathione

ICU

Intensive care unit

MDA

Malondialdehyde

NP-SH

Nonprotein sulfhydryl

NSAID

Nonsteroidal anti-inflammatory drug

PGE2

Prostaglandin E2

ROS

Reactive oxygen species

SOD

Superoxide dismutase

TF

Tocopherol

TNF-α

Tumor necrosis factor alpha

TT

Tocotrienol

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Mohd Fahami Nur Azlina
    • 1
  • Haji Mohd Saad Qodriyah
    • 1
  • Yusof Kamisah
    • 1
  1. 1.Department of Pharmacology, Faculty of Medicine, PPUKMUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia

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