COP9 Signalosome Network
The COP9 signalosome (CSN) is an evolutionary conserved multiprotein complex that functions in the ubiquitin–proteasome pathway.
The CSN has an isopeptidase activity which removes the NEDD8 peptide from the cullin–RING ubiquitin ligases (CRLs). This reaction ensures the proper function of the CRLs.
The CSN is involved in the control of multiple signaling processes in virtually all eukaryotes. In plants, the CSN takes part in a plethora of developmental processes and environmental responses, including photomorphogenesis, flower development, hormone signaling, and plant pathogen response.
The CSN is also required for the regulation of cellular pathways, such as cell cycle, DNA repair, and regulation of gene expression.
KeywordsUbiquitin Ligase Auxin Signaling DELLA Protein COP9 Signalosome eIF3 Complex
- Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest. 2011;121(3):851–65.PubMedCrossRefPubMedCentralGoogle Scholar