Fig. 1
From: Acral Melanoma
Typical clinical and histopathologic features of acral melanoma. Clinically, this lesion on the heel exhibits an ulcerated nodule, accompanying ill-defined brown macules with variable shades, interposed by seemingly nonpigmented areas (a). Macular portions histopathologically show proliferation of atypical melanocytes as solitary units and in nests of variable size within the epidermis (b). Upward migration of atypical melanocytes is detected in the hyperplastic epidermis with some elongation of the rete ridges