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Bradykinesia is the cardinal symptom of Parkinson’s disease (PD). It is related to an abnormal slowness of movement. The causes of PD bradykinesia are not known largely, because there are multiple brain areas and pathways involved from the neuronal degeneration site (dopamine neurons in substantia nigra pars compacta (SNc) and ventral tegmental area (VTA)) to the muscles. Bradykinesia models are mathematical and computational constructs attempting to uncover how information is processed in the affected brain areas and what are the biophysical mechanisms giving rise to the observed slowness of movement in PD bradykinesia.
Bradykinesia, the hallmark and most disabling symptom of PD, refers to an extreme slowness of movement. In early stages of the disease, PD patients have difficulties with daily activities such as walking, speaking, or getting in and out of chairs (Gibberd 1986). In the later phases...
KeywordsVentral Tegmental Area Dopamine Neuron Globus Pallidus External Output Nucleus Basal Ganglion Output
- Bjorklund A, Lindvall O (1984) Dopamine containing systems in the CNS. In: Bjorklund A, Hokfelt T (eds) Handbook of chemical neuroanatomy. Classical transmitters in the CNS, Part 1, vol 2. Elsevier, Amsterdam, pp 55–121Google Scholar
- Cutsuridis V (2006a) Biologically inspired neural architectures of voluntary movement in normal and disordered states of the brain. Unpublished PhD dissertationGoogle Scholar
- Cutsuridis V (2006b) Neural model of dopaminergic control of arm movements in Parkinson’s disease bradykinesia. In: Kolias S, StafilopatisA, Duch W (eds) ICANN 2006: artificial neural networks. LNCS, vol 4131. Springer, Berlin, pp 583–591Google Scholar
- Cutsuridis V (2013) Bradykinesia models of Parkinson’s disease. Scholarpedia, under reviewGoogle Scholar