Living Reference Work Entry

Encyclopedia of Computational Neuroscience

pp 1-10

Date: Latest Version

Local Field Potential Interaction with the Extracellular Medium

  • Claude BédardAffiliated withUnit of Neuroscience Information and Complexity, Centre national de la recherche scientifique Email author 
  • , Alain DestexheAffiliated withUnit of Neuroscience Information and Complexity, Centre national de la recherche scientifique

Definition

The local field potential (LFP) is the electric potential in the extracellular space around neurons. The LFP is generated by electric currents and charges and is also interacting in several possible ways with the extracellular medium, such as capacitive interactions, polarization, or trough ionic diffusion. These types of interaction confer specific frequency dependence of the extracellular electric potential and thus are important for correctly interpreting the LFP, as well as estimating the underlying neuronal sources (inverse problem).

Detailed Description

Introduction

In contrast to the electroencephalogram (EEG) recorded at the surface of the scalp, the local field potential (LFP) is recorded by inserting microelectrodes into neural tissue, and it is recordable using a variety of electrode systems, such as metal or silicon electrodes or glass micropipettes. Early studies established that action potentials have a limited participation to EEGs or LFPs (Bremer 1938, 1949; Eccl ...

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