Retinal Disease and Remodeling
Retinal remodeling is a collection of pathologic changes in the structure and function of the neural retina triggered by photoreceptor degenerations.
Diseases That Cause Retinal Remodeling
Retinal remodeling is initiated by inherited gene defects and gene-risk coupled environmental stressors that lead to photoreceptor degeneration (Jones et al. 2003, 2012; Marc et al. 2003), e.g., retinitis pigmentosa (RP) and macular degeneration (AMD). Over 100 gene loci are associated with RP-like degenerations (Daiger and Sullivan 2013). Most RP-like degenerations directly affect rods, leaving many cones intact. Rod death can, however, trigger extensive bystander killing of cones. These different effects have been classified as cone sparing and cone decimating (Marc et al. 2007). After photoreceptor death, the surviving retina progressively changes form and signaling properties. Remodeling progression depends on the nature of the primary degeneration. Recessive RP...
KeywordsRetinitis Pigmentosa Bipolar Cell Retinoic Acid Receptor Outer Nuclear Layer Retinal Pigment Epithelium
- Daiger SP, Sullivan LS (2013) Retinal information network. http://www.sph.uth.tmc.edu/Retnet/. Accessed 14 Sep 2013
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