Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Retinal Disease and Remodeling

  • Robert E. MarcEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_659-1

Definition

Retinal remodeling is a collection of pathologic changes in the structure and function of the neural retina triggered by photoreceptor degenerations.

Detailed Description

Diseases That Cause Retinal Remodeling

Retinal remodeling is initiated by inherited gene defects and gene-risk coupled environmental stressors that lead to photoreceptor degeneration (Jones et al. 2003, 2012; Marc et al. 2003), e.g., retinitis pigmentosa (RP) and macular degeneration (AMD). Over 100 gene loci are associated with RP-like degenerations (Daiger and Sullivan 2013). Most RP-like degenerations directly affect rods, leaving many cones intact. Rod death can, however, trigger extensive bystander killing of cones. These different effects have been classified as cone sparing and cone decimating (Marc et al. 2007). After photoreceptor death, the surviving retina progressively changes form and signaling properties. Remodeling progression depends on the nature of the primary degeneration. Recessive RP...

Keywords

Retinitis Pigmentosa Bipolar Cell Retinoic Acid Receptor Outer Nuclear Layer Retinal Pigment Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Daiger SP, Sullivan LS (2013) Retinal information network. http://www.sph.uth.tmc.edu/Retnet/. Accessed 14 Sep 2013
  2. Jones BW, Kondo M, Terasaki H, Lin Y, McCall M, Marc RE (2012) Retinal remodeling. Jpn J Ophthalmol 56:289–306PubMedCentralPubMedCrossRefGoogle Scholar
  3. Jones BW, Watt CB, Frederick JM, Baehr W, Chen CK, Levine EM, Milam AH, LaVail MM, Marc RE (2003) Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 464:1–16PubMedCrossRefGoogle Scholar
  4. Lin Y, Jones BW, Liu A, Tucker JF, Rapp K, Luo L, Baehr W, Bernstein PS, Watt CB, Yang J-H, Shaw MV, Marc RE (2011) Retinoid receptors trigger neuritogenesis in retinal degenerations. FASEB J 26:81–92PubMedCrossRefGoogle Scholar
  5. Marc RE, Jones BW, Anderson JR, Kinard K, Marshak DW, Wilson JH, Wensel T, Lucas RJ (2007) Neural reprogramming in retinal degeneration. Invest Ophthalmol Vis Sci 48:3364–3371PubMedCentralPubMedCrossRefGoogle Scholar
  6. Marc R, Jones BW, Watt CB (2005) Retinal remodeling: circuitry revisions triggered by photoreceptor degeneration. In: Pinaud R et al (eds) Plasticity in the visual system: from genes to circuits. Springer, New York, pp 33–54Google Scholar
  7. Marc RE, Jones BW, Watt CB, Strettoi E (2003) Neural remodeling in retinal degeneration. Prog Retin Eye Res 22:607–655PubMedCrossRefGoogle Scholar
  8. Margolis DJ, Newkirk G, Euler T, Detwiler PB (2008) Functional stability of retinal ganglion cells after degeneration-induced changes in synaptic input. J Neurosci 28:6526–6536PubMedCentralPubMedCrossRefGoogle Scholar
  9. Toychiev AH, Ivanova E, Yee CW, Sagdullaev BT (2013) Block of gap junctions eliminates aberrant activity and restores light responses during retinal degeneration. J Neurosci 33:13972–13977PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.John A. Moran Eye CenterUniversity of UtahSalt Lake CityUSA